852248-61-4

Upstream product

• 3282-30-2 pivaloyl chloride 
• 852248-60-3 (4S,5S)-7-(tert-Butyl-dimethyl-silanyloxymethyl)-6,6,8-trimethyl-4-{(S)-2-methyl-1-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-allyl}-1,3-dioxa-spiro[4.5]dec-7-en-2-one 
• 852248-59-0 (S)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-1-{(1S,2R)-1-hydroxy-3-methyl-2-[(R)-((S)-2-phenyl-[1,3]dioxan-4-yl)-(2-trimethylsilanyl-ethoxymethoxy)-methyl]-but-3-enyl}-2,2,4-trimethyl-cyclohex-3-enol 

Relevant academic research and scientific papers

Synthesis of the AC ring of paclitaxel: Formation of the C ring by [3+2] cycloaddition with a preformed A ring

The stereoselective formation of the C ring was accomplished by nitrile oxide [3+2] cycloaddition of an intermediate with the A ring already constructed. We found that stereoelectronic effect to a 1,1-substituted alkene moiety is important in the reaction