852316-01-9Relevant academic research and scientific papers
Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists
Debenham, John S.,Madsen-Duggan, Christina B.,Walsh, Thomas F.,Wang, Junying,Tong, Xinchun,Doss, George A.,Lao, Julie,Fong, Tung M.,Schaeffer, Marie-Therese,Xiao, Jing Chen,Huang, Cathy R.-R. C.,Shen, Chun-Pyn,Feng, Yue,Marsh, Donald J.,Stribling, D. Sloan,Shearman, Lauren P.,Strack, Alison M.,MacIntyre, D. Euan,Van Der Ploeg, Lex H. T.,Goulet, Mark T.
, p. 681 - 685 (2007/10/03)
Synthesis, SAR, and binding affinities are described for a new class of 1,8-naphthyridinone CB1 receptor specific inverse agonists. Food intake, knockout mouse, and pharmacokinetic evaluation of 14 indicate that this compound is an effective orally active
SUBSTITUTED NAPHTHYRIDINONE DERIVATIVES
-
Page/Page column 83, (2010/02/11)
Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present in
