852333-34-7

Basic information

• Product Name: 5,6,7-trihydroxy-2-phenyl-8-(thiomorpholinomethyl)-4H-chromen-4-one
• Synonyms: 5,6,7-trihydroxy-2-phenyl-8-(thiomorpholinomethyl)-4H-chromen-4-one
• CAS NO: 852333-34-7
• Molecular Weight: 385.441
• Mol File: 852333-34-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5,6,7-trihydroxy-2-phenyl-8-(thiomorpholinomethyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7-trihydroxy-2-phenyl-8-(thiomorpholinomethyl)-4H-chromen-4-one(852333-34-7)
• EPA Substance Registry System: 5,6,7-trihydroxy-2-phenyl-8-(thiomorpholinomethyl)-4H-chromen-4-one(852333-34-7)

Safety Data

• Hazardous Substances Data: 852333-34-7(Hazardous Substances Data)

Upstream product

• 123-90-0 Thiomorpholin 
• 50-00-0 formaldehyd 
• 491-67-8 5,6,7-trihydroxy-2-phenyl-4H-1-benzopyran-4-one 

Relevant articles and documents

Design, synthesis, and primary activity assays of baicalein derivatives as cyclin-dependent kinase 1 inhibitors

Malignant tumor is a disease with high mortality. Traditional treatment methods have many disadvantages, such as side-effects, drug resistance. Because cyclin-dependent kinase 1 (CDK1) plays an indispensable role in cell cycle regulation, it became an att

Nitrogen-containing flavonoid analogues as CDK1/cyclin B inhibitors: Synthesis, SAR analysis, and biological activity

A series of nitrogen-containing flavonoid analogues were designed and synthesized by Mannich reaction, and screened for the inhibitory activities of cyclin-dependent kinases using a FRET-based biochemical assay method. The results showed that C-8 nitrogen-containing baicalein analogues 3a-3f exhibited potent CDK1/Cyclin B inhibitory activities. 5,6,7-Trihydroxy-8-(dimethylaminomethyl)-2-phenyl-4H-chromen-4-one 3a, 5,6,7-trihydroxy-8-(pyrrolid inylmethyl)-2-phenyl-4H-chromen-4-one 3b, and 5,6,7-trihydroxy-8-(piperidinylmethyl)-2-phenyl-4H-chromen-4-one 3c (IC50 1.05-1.28 μM) were about sixfold more potent than baicalein 2 (IC50 6.53 μM). 5,6,7-Trihydroxy-8-(morpholinomethyl)-2-phenyl-4H-chromen-4-one 3d, 5,6,7-trihydroxy-8-(thiomorpholinomethy)-2-phenyl-4H-chrom en-4-one 3e, and 5,6,7-trihydroxy-8-(4-methylpiperazinylmethyl)-2-phenyl-4H-chromen-4-one 3f (IC50 0.27-0.38 μM) were about 20-fold more potent than baicalein, and were at the same level as flavopiridol (IC50 0.33 μM).