852355-43-2

Upstream product

• 757916-00-0 3,5-dicarboxyphenyl glycinamide 
• 501-53-1 benzyl chloroformate 
• 1138-80-3 N-(Benzyloxycarbonyl)glycine 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 99-31-0 5-aminoisophthalic acid 
• 61389-11-5 3,5-dicarboxyphenyl chloroacetamide 

Downstream Products

• 852355-48-7 C₅₄H₆₄N₆O₁₅ 
• 940005-75-4 [(3,5-bis{(3,5-bis-(prop-2-ynylcarbamoyl)phenylcarbamoyl)methylcarbamoyl}phenylcarbamoyl)methyl]-carbamic acid benzyl ester 
• 940005-71-0 [(3,5-bis(prop-2-ynylcarbamoyl)phenylcarbamoyl)-methyl]carbamic acid benzyl ester 
• 866325-27-1 NH₂CH₂CONHC₆H₃(CONHC(CH₂OC₂H₄CO₂C(CH₃)3)3)2 
• 852355-49-8 C₄₆H₅₈N₆O₁₃ 

Relevant academic research and scientific papers

THERAPEUTIC METHODS

The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.

METHODS FOR TREATING HEPATITIS B INFECTIONS

Certain embodiments of the invention provide a method for identifying a patient that has a higher likelihood of responding to an HBV antigen inhibitor, such a method comprising detecting a hepatitis B virus (HBV) infected patient's genotype at one or more of the IL28B/A associated SNPs described herein, wherein the relevant genotype(s) described herein are indicative of a patient that has a higher likelihood of responding to an HBV antigen inhibitor as compared to an HBV infected patient having different genotypes at these locations.

TARGETED COMPOSITIONS

The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

TARGETED NUCLEIC ACID CONJUGATE COMPOSITIONS

The invention provides conjugates that comprise a targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic nucleic acids to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).

Robust multidentate ligands for diagnosis and anti-viral drugs for influenza and related viruses

Design and synthesis of a novel library of compounds comprising a spacer with an attachment element on one terminus and a recognition element on the other terminus is presented. The library of compounds can be attached to a solid support and used as an in

Synthesis of soluble multivalent glycoconjugates that target the Hc region of botulinum neurotoxin A

The design, synthesis, and initial inhibitory studies of di- and tetravalent glycoconjugates that target the heavy chain of botulinum neurotoxin A are reported.

Arylamide dendrimers with flexible linkers via haloacyl halide method

(Chemical Equation Presented) Soluble arylamide dendrons with flexible linkers, peripheral ester or carboxyl groups (R), and focal amino or halogen functionalities (F) were synthesized from aryl glycineamide (AG) building blocks. The AG blocks were prepar