85236-95-9 Usage
Uses
Used in Antiviral Applications:
Uridine, 3'-amino-2',3'-dideoxy-5-fluorois used as an antiviral agent for its ability to inhibit viral replication. The 2',3'-dideoxy modification in its structure prevents the synthesis of DNA, making it a potential candidate for treating viral infections.
Used in Antitumor Applications:
Uridine, 3'-amino-2',3'-dideoxy-5-fluorois used as an antitumor agent due to its enhanced antitumor activity provided by the 5-fluoro substitution. Uridine, 3'-amino-2',3'-dideoxy-5-fluorohas shown potential in targeting and inhibiting the growth of cancer cells, making it a promising candidate for cancer therapy.
Used in Pharmaceutical Research:
Uridine, 3'-amino-2',3'-dideoxy-5-fluorois used as a research compound in the development of new antiviral and antitumor drugs. Its unique structure and properties make it a valuable tool for understanding the mechanisms of action and potential therapeutic applications in the field of medicine. Further studies are needed to fully explore its potential and optimize its use in clinical settings.
Check Digit Verification of cas no
The CAS Registry Mumber 85236-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,5,2,3 and 6 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 85236-95:
(7*8)+(6*5)+(5*2)+(4*3)+(3*6)+(2*9)+(1*5)=149
149 % 10 = 9
So 85236-95-9 is a valid CAS Registry Number.
85236-95-9Relevant academic research and scientific papers
Krenitsky,Freeman,Shaver,Beacham III,Hurlbert,Cohn,Elwell,Selway
, p. 891 - 895 (1983)
3'-Amino-2',3'-dideoxyribonucleosides of thymine, uracil, and 5-iodouracil (1-3) were synthesized from the corresponding 2'-deoxyribonucleosides via the threo-3'-chloro and the erythro-3'-azido derivatives. Corresponding aminonucleosides of 5-bromouracil, 5-chlorouracil, and 5-fluorouracil (4-6) were synthesized enzymatically with 3'-amino-2',3'-dideoxythymidine as the aminopentosyl donor and thymidine phosphorylase (EC 2.4.2.4) as the catalyst. 3'-Amino-2',3'-dideoxycytidine (7) was synthesized by amination of the 3'-azido precursor of 3'-amino-2',3'-dideoxyuridine. The biological activity of 3'-amino-2',3'-dideoxy-5-fluorouridine (6) was notable among this group of aminonucleosides. It had an ED50 of 10 μM against adenovirus and was not appreciably cytotoxic to mammalian cells in culture. It also had activity against some Gram-positive bacteria but not against a variety of Gram-negative bacteria. The other aminonucleosides (1-5 and 7) lacked or exhibited weak antiviral and antibacterial activities. The only compounds in this group that were appreciably toxic to mammalian cells in culture were the thymidine and deoxycytidine analogues (1 and 7).
