96699-71-7

Basic information

• Product Name: 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine
• Synonyms: 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine;3'-Cfdunu;Uridine, 3'-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-2',3'-dideoxy-5-fluoro-
• CAS NO: 96699-71-7
• Molecular Formula: C12H15ClFN5O6
• Molecular Weight: 379.7288032
• Mol File: 96699-71-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine(96699-71-7)
• EPA Substance Registry System: 3'-(3-(2-chloroethyl)-3-nitrosoureido)-2',3'-dideoxy-5-fluorouridine(96699-71-7)

Safety Data

• Hazardous Substances Data: 96699-71-7(Hazardous Substances Data)

Upstream product

• 87190-74-7 1-(3-azido-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-fluorouracil 
• 85236-95-9 1-(3-amino-2,3-dideoxy-β-D-erythro-pentofuranosyl)-5-fluorouracil 
• 96699-70-6 3'-<3-(2-chloroethyl)ureido>-2',3'-dideoxy-5-fluorouridine 

Relevant articles and documents

Antineoplastic Activity of 3'-(Chloroethyl)nitrosourea Analogues of 2'-Deoxyuridine and 2'-Deoxy-5-fluorouridine

The (chloroethyl)nitrosourea analogues of 2'-deoxyuridine and 2'-deoxy-5-fluorouridine, 3'--2',3'-dideoxyuridine (3'-CdUNU, 7) and 3'--2',3'-dideoxy-5-fluorouridine (3'-CFdUNU, 8), have been synthesized by treatment of the corresponding 3'-amino nucleosides with chloroethyl isocyanate, followed by nitrosation of the resulting ureas.Nucleoside nitrosoureas 7 and 8 exhibited marked anticancer activity against L1210 leukemia in tumor-bearing mice.At an optimum dosage level of 40 mg/kg, 7 and 8 produced 90percent and 60percent "cures" (>60-day survivors), respectively.The structure-activity relationships are discussed.