852367-19-2

Basic information

• Product Name: 2-(4-(DIPHENYLMETHYL)PIPERAZINYL)-1-INDOL-3-YLETHANE-1,2-DIONE
• Synonyms: 2-(4-(DIPHENYLMETHYL)PIPERAZINYL)-1-INDOL-3-YLETHANE-1,2-DIONE;1-[4-(diphenylmethyl)piperazin-1-yl]-2-(1H-indol-3-yl)ethane-1,2-dione
• CAS NO: 852367-19-2
• Molecular Formula: C27H25N3O2
• Molecular Weight: 423.51
• Mol File: 852367-19-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-(DIPHENYLMETHYL)PIPERAZINYL)-1-INDOL-3-YLETHANE-1,2-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(DIPHENYLMETHYL)PIPERAZINYL)-1-INDOL-3-YLETHANE-1,2-DIONE(852367-19-2)
• EPA Substance Registry System: 2-(4-(DIPHENYLMETHYL)PIPERAZINYL)-1-INDOL-3-YLETHANE-1,2-DIONE(852367-19-2)

Safety Data

• Hazardous Substances Data: 852367-19-2(Hazardous Substances Data)

Upstream product

• 22980-09-2 indolyl-3-glyoxylyl chloride 
• 841-77-0 diphenylmethylpiperazine 
• 90-99-3 diphenylchloromethane 
• 91-01-0 1,1-Diphenylmethanol 
• 119-61-9 benzophenone 
• 120-72-9 indole 

Relevant articles and documents

Synthesis and Anticancer Activity of 1-(1H -Indol-3-yl)-2-(4-diarylmethylpiperazine-1-yl)ethane-1,2-dione Derivatives

Several new 1-(4-diarylmethylpiperazine-1-yl)-2-(1H-indol-3-yl)ethane-1,2-dione derivatives were synthesized by acylation of 1-diarylmethylpiperazine with 2-(1H-indol-3-yl)-2-oxoacetyl chloride. Their structures were confirmed by 1H NMR, IR, mass spectra, and elemental analysis. These compounds were further evaluated for their anticancer activity, and most of them were found to have moderate-to-potent antiproliferative activities against Hela, A-549, and ECA-109 cancer cell lines in vitro.