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Usage

Uses

Used in Pharmaceutical Industry:
2-(p-tolyl)piperidine is utilized as a key building block for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for the creation of a wide range of organic compounds with diverse medicinal properties.
Used in Organic Chemistry:
As a precursor, 2-(p-tolyl)piperidine is employed in the production of other piperidine derivatives, which are essential components in various chemical and pharmaceutical applications. Its versatility in chemical reactions makes it a valuable intermediate in organic synthesis.
Used in Biological Research:
2-(p-tolyl)piperidine is studied for its potential biological activities, particularly its effects on the central nervous system. This research aims to explore its possible applications in the development of treatments for neurological disorders and other related conditions.

Upstream product

• 105902-02-1 6-p-tolyl-2,3,4,5-tetrahydro-pyridine 
• 6280-87-1 δ-chlorovaleronitrile 
• 4467-06-5 2-(4-methylphenyl)pyridine 
• 106-38-7 para-bromotoluene 

Downstream Products

• 118087-41-5 2-p-Tolyl-1-trimethylsilanylmethyl-piperidine 
• 118087-43-7 1-Methyl-2-p-tolyl-1-trimethylsilanylmethyl-piperidinium; iodide 

Relevant academic research and scientific papers

A General Catalyst Based on Cobalt Core–Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines

Herein, we report the synthesis of specific silica-supported Co/Co3O4 core–shell based nanoparticles prepared by template synthesis of cobalt-pyromellitic acid on silica and subsequent pyrolysis. The optimal catalyst material allows for general and selective hydrogenation of pyridines, quinolines, and other heteroarenes including acridine, phenanthroline, naphthyridine, quinoxaline, imidazo[1,2-a]pyridine, and indole under comparably mild reaction conditions. In addition, recycling of these Co nanoparticles and their ability for dehydrogenation catalysis are showcased.

Radical cyclisations of imines and hydrazones

Radical cyclisation of sp3 carbon-centred radicals onto imines and hydrazones provides a new method for the synthesis of 5- and 6-membered ring nitrogen heterocycles. Cyclisation onto the electrophilic carbon of the C=N group and 5-exo stereoelectronic selectivity are the dominating mechanistic parameters. The C-centred radical intermediates were generated from benzeneselenyl precursors using Bu3SnH.