852370-09-3

Usage

Type of compound

Medication

Use

Treats transthyretin amyloidosis, a rare genetic condition caused by the accumulation of abnormal protein deposits in tissues and organs

Mechanism of action

Stabilizes the transthyretin protein, preventing its aggregation and deposition in tissues, which slows down the progression of the disease and improves quality of life

Form

Capsule for oral administration

Approval status

Approved for use in several countries

Upstream product

• 392-04-1 methyl 4-fluoro-2-hydroxybenzoate 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 

Downstream Products

• 852370-10-6 methyl 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(pyrrolidin-1-yl)benzoate 
• 852370-75-3 methyl 2-[1-(tert-butoxycarbonyl)piperidin-4-yloxy]-4-(N,N-dimethylamino)-benzoate 

Relevant academic research and scientific papers

AROMATIC ETHER DERIVATIVES USEFUL AS THROMBIN INHIBITORS

This application relates to a compound of formula (I) (or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor. An example of a compound of formula (I) is (a).

ANTITHROMBOTIC AROMATIC ETHERS

This application relates to a compound of formula (I) (or a prodrug thereof or a pharmaceutically acceptable salt of the compound or prodrug thereof) as defined herein, pharmaceutical compositions thereof, and its use as an inhibitor of factor Xa and/or thrombin, as well as a process for its preparation and intermediates therefor.