852414-57-4

Basic information

• Product Name: N¹,N²-bis(2,4,6-trimethylphenyl)-1,2-benzenediamine
• Synonyms: N¹,N²-bis(2,4,6-trimethylphenyl)-1,2-benzenediamine
• CAS NO: 852414-57-4
• Molecular Weight: 344.5
• Mol File: 852414-57-4.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: N¹,N²-bis(2,4,6-trimethylphenyl)-1,2-benzenediamine(CAS DataBase Reference)
• NIST Chemistry Reference: N¹,N²-bis(2,4,6-trimethylphenyl)-1,2-benzenediamine(852414-57-4)
• EPA Substance Registry System: N¹,N²-bis(2,4,6-trimethylphenyl)-1,2-benzenediamine(852414-57-4)

Safety Data

• Hazardous Substances Data: 852414-57-4(Hazardous Substances Data)

Upstream product

• 88-05-1 2,4,6-trimethylaniline 
• 583-53-9 2,3-dibromobenzene 
• 108-94-1 cyclohexanone 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 1374986-92-1 5-(2,4,6-trimethylphenyl)-1,3,4a-trimethyl-4a,5-dihydrophenazine 
• 1418747-32-6 2-bromo-1,3-dimesityl-1,3,2-benzodiazaborole 

Relevant articles and documents

Sterically demanding and chiral N,N′-disubstituted N-heterocyclic germylenes and stannylenes

The N,N′-dimesitylene substituted o-phenylenediamine 1 reacts with Sn[N(SiMe3)2]2 under formation of the monomeric N-heterocyclic stannylene 2, while the chiral N,N′-substituted o-phenylenediamine 3 reacts with E[N(SiMesu

A facile synthetic route to benzimidazolium salts bearing bulky aromatic N-substituents

An atom-economic synthetic route to benzimidazolium salts is presented. The annulated polycyclic systems: 1,3-bis(2,4,6- Trimethylphenyl)-1H-benzo[d]imidazol-3-ium chloride (1-Cl), 1,3-bis(2,6-diisopropylphenyl)-1H-benzo[d]imidazol-3-ium chloride (2-Cl),

Synthesis, characterization, molecular structures, cytotoxic and antibacterial activities of N,N′-diaryl-o-phenylenediamines

The molecular structures of N,N′-2,6-dimethylphenyl-o- phenylenediamine (1), N,N′-2,4,6-trimethylphenyl-o-phenylenediamine (2), N,N′-2,6-diisopropylphenyl-o-phenylenediamine 3a and 3b (dimorph of 3a) have been elucidated by X-ray diffraction as well as characterized by FT-IR, HRMS, 1H, 13C NMR and 2D experiments. The cytotoxic and antibacterial activities of the N,N′-diaryl-o-phenylenediamines (1-3) were tested against human tumor cell lines A431 and MOLT4 and Salmonella typhimurium and Staphylococcus aureus respectively. Compounds 1 and 2 showed higher biological activities than compound 3 in cell line A431 and against S. typhimurium. Tumor cell growing was inhibited with 1 and 2 1.0 μg/mL and 0.5 μg/mL, respectively. The minimal inhibitory concentration against S. typhimurium and S. aureus for both compounds was 0.35 μg/mL. However, all compounds presented very similar activities in cell line MOLT4 (1-3: 0.5 μg/mL) and S. aureus (1-3: 0.35 μg/mL). A decrease of steric hindrance on phenylenediamine derivatives might influence on biological activity.