852443-99-3 Usage
Uses
Used in Pharmaceutical Industry:
2,2,2-Trifluoro-1-(4-fluoro-phenyl)-ethylamine is used as a building block for the synthesis of pharmaceutical compounds, leveraging its unique structure and fluorinated nature to enhance the properties of the resulting drugs. The incorporation of fluorine atoms can improve the pharmacokinetics, bioavailability, and potency of the final drug products.
Used in Agrochemical Industry:
In the agrochemical sector, 2,2,2-Trifluoro-1-(4-fluoro-phenyl)-ethylamine is utilized as a precursor in the development of new agrochemicals, such as pesticides and herbicides. Its fluorinated structure can contribute to the increased effectiveness and selectivity of these compounds, leading to improved crop protection.
Used in Materials Science:
2,2,2-Trifluoro-1-(4-fluoro-phenyl)-ethylamine is employed in materials science for the synthesis of novel materials with specific properties. Its fluorinated nature can impart unique characteristics to the resulting materials, such as enhanced thermal stability, chemical resistance, or specific electronic properties, making them suitable for various applications in industries like electronics, automotive, and aerospace.
Check Digit Verification of cas no
The CAS Registry Mumber 852443-99-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,2,4,4 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 852443-99:
(8*8)+(7*5)+(6*2)+(5*4)+(4*4)+(3*3)+(2*9)+(1*9)=183
183 % 10 = 3
So 852443-99-3 is a valid CAS Registry Number.
InChI:InChI=1/C8H7F4N/c9-6-3-1-5(2-4-6)7(13)8(10,11)12/h1-4,7H,13H2
852443-99-3Relevant academic research and scientific papers
Silver-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides: a facile stereoselective synthesis of CF3-substituted heterocycles
Zhang, Xue,Wang, Xin,Gao, Yuelei,Xu, Xianxiu
supporting information, p. 2427 - 2430 (2017/03/01)
An Ag-catalyzed formal [3+2]-cycloaddition of α-trifluoromethylated methyl isocyanides with polar double bonds has been developed for the facile access to trifluoromethylated oxazolines, imidazolines and pyrrolines under mild conditions. The practicality of this chemistry is demonstrated by the gram-scale synthesis of oxazolines with excellent yields and facile transformations of the formed oxazolines to trifluoromethylated β-amino alcohols in quantitative yields.
PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES
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Page/Page column 92, (2008/06/13)
Compounds of formula (I): and their use in the inhibition of Trk activity are described.
