852459-67-7

Upstream product

• 530-26-7 D-Mannose 
• 182212-07-3 α,β-O-allyl-D-mannopyranoside 
• 852459-70-2 2,4,6-tri-O-benzyl-3-O-(4-methoxybenzyl)-D-mannono-1,5-lactone 

Downstream Products

• 852459-72-4 (2R,3S,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-((2R,3R,4S,5S)-3,5-bis-benzyloxy-2-benzyloxymethyl-6-methylene-tetrahydro-pyran-4-yloxy)-6-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-pyran 
• 852459-68-8 (3S,4S,5R,6R)-3,5-Bis-benzyloxy-6-benzyloxymethyl-4-[(2R,3S,4S,5R,6R)-3,4,5-tris-benzyloxy-6-(4-methoxy-benzyloxymethyl)-2-methyl-tetrahydro-pyran-2-yloxy]-tetrahydro-pyran-2-one 
• 852459-70-2 2,4,6-tri-O-benzyl-3-O-(4-methoxybenzyl)-D-mannono-1,5-lactone 

Relevant academic research and scientific papers

Synthesis of 1-deoxyhept-2-ulosyl-glycono-1,5-lactone utilizing α-selective O-glycosidation of 2,6-anhydro-1-deoxy-d-hept-1-enitols

A series of 1-deoxy-heptulo-2-pyranosyl-glycono-1,5-lactones were synthesized utilizing completely α-selective O-glycosidation of heptenitols. Anomeric configuration of the products was confirmed by 3JC,H coupling measurement and X-ray crystal structural analysis. The benzyl-protected ketosyl saccharides were partly unstable, and glycosidic linkage was prone to cleave under the usual debenzylation conditions. To prevent this, we surveyed various additives for the Pd-catalyzed hydrogenation reaction and found that basic alumina was the most effective.