852620-79-2

Upstream product

• 20776-50-5 2-amino-4-bromobenzoic acid 
• 57848-46-1 4-bromo-2-fluorobenzaldehyde 
• 1334950-91-2 2-azido 4-bromobenzaldehyde 

Downstream Products

• 852620-80-5 2-azido-4-bromo-N-(4-(trifluoromethyl)phenyl)benzamide 
• 1373844-83-7 2-azido-4-bromo-N-(4-fluorophenyl)benzamide 
• 1373844-85-9 6-bromo-3-chloro-2-(4-fluorophenyl)-2H-indazole 
• 1373844-87-1 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carbonitrile 
• 1373844-89-3 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxamide 
• 1373844-91-7 6-bromo-2-(4-fluorophenyl)-2H-indazole-3-carboxylic acid 
• 1373844-93-9 6-bromo-2-(4-fluorophenyl)-N-methyl-2H-indazole-3-carboxamide 
• 1352082-80-4 3-cyclohexyl-N-(dimethylsulfamoyl)-2-phenyl-2H-indazole-6-carboxamide 
• 1352082-79-1 3-(cyclohex-1-en-1-yl)-N-(dimethylsulfamoyl)-2-phenyl-2H-indazole-6-carboxamide 
• 1352082-77-9 3-cyclohexyl-N-[1-({4-[(1E)-3-(methylamino)-3-oxoprop-1-en-1-yl]phenyl}carbamoyl)cyclobutyl]-2-phenyl-2H-indazole-6-carboxamide 
• 1352083-34-1 3-cyclohexyl-2-phenyl-2H-indazole-6-carboxamide 
• 1352082-76-8 3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)propanoic acid 
• 1352082-75-7 (2E)-3-(4-{[(1-{[(3-cyclohexyl-2-phenyl-2H-indazol-6-yl)carbonyl]amino}cyclobutyl)carbonyl]amino}phenyl)prop-2-enoic acid 
• 1352082-73-5 3-cyclohexyl-2-phenyl-2H-indazole-6-carboxylic acid 

Relevant academic research and scientific papers

The search for novel TRPV1-antagonists: From carboxamides to benzimidazoles and indazolones

Based on a series of diaryl amides the corresponding inverse amides have been found to be potent TRPV1 receptor antagonists. Benzimidazole and indazolone derivatives prepared retained good potency in vitro and indazolone 4a was identified as a novel TRPV1 receptor antagonist suitable for evaluating orally in animal models of analgesia.

Novel substituted triazolo benzodiazepine scaffolds to explore chemical space

Efficient and concise routes to sets of novel triazolo-1,4-benzodiazepine scaffolds that are suitably functionalized for diversification at three positions to explore three-dimensional space with different substituents are described. One approach to these scaffolds features a simplified multicomponent assembly process to give an intermediate azido alkyne that undergoes a facile Huisgen dipolar cycloaddition. The triazolo-1,4-benzodiazepines thus produced may be endowed with aryl halide, secondary amino, alcohol, aldehyde or carboxylic acid groups as functional handles for orthogonal derivatization reactions. Modification of this approach enabled the facile synthesis of the related triazolo-1,4-benzodiazepin-6-ones, also bearing three functional handles. These convenient protocols were used to prepare multi-gram quantities of benzodiazepine analogs as precursors for generating compound libraries for screening campaigns.

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, solvates, hydrates, racemates, enantiomers or isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C virus (HCV) infections: (I)

VIRAL POLYMERASE INHIBITORS

The present invention relates to viral polymerase inhibitors of formula (I), salts, N-oxides, racemates, enantiomers and isomers thereof, processes for their preparation and their use in the treatment of Flaviviridae viral infections such as Hepatitis C v

INDAZOL-3-ONES AND ANALOGUES AND DERIVATIVES THEREOF WHICH MODULATE THE FUNCTION OF THE VANILLOID-1 RECEPTOR (VR1)

Compounds of formula (I), which are useful as therapeutic compounds, particularly in the treatment of pain and other conditions ameliorated by the modulation of the function of the vanilloid-1 receptor (VR1).