852622-91-4Relevant academic research and scientific papers
Controlled synthesis of cis or trans isomers of 1,3-disubstituted tetrahydroisoquinolines and 2,5-disubstituted pyrrolidines
Eustache, Jacques,Van De Weghe, Pierre,Le Nouen, Didier,Uyehara, Hiroshi,Kabuto, Chizuko,Yamamoto, Yoshinori
, p. 4043 - 4053 (2007/10/03)
The stereoselective outcome of Pd(II)- or Ag(I)-catalyzed intramolecular N-alkylation to afford 1,3-disubstituted 1,2,3,4-tetrahydroisoquinolines was examined. In the absence of additional substituents, Pd(II) allows a facile access to the cis isomers, wh
