852633-21-7

Basic information

• Product Name: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
• Synonyms: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
• CAS NO: 852633-21-7
• Molecular Weight: 517.661
• Mol File: 852633-21-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(852633-21-7)
• EPA Substance Registry System: 4-(tert-butyl-dimethyl-silanyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester(852633-21-7)

Safety Data

• Hazardous Substances Data: 852633-21-7(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 114676-91-4 1-tert-butyl 2-methyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}pyrrolidine-1,2-dicarboxylate 
• 402-49-3 4-bromomethyltrifluoromethylbenzene 

Downstream Products

• 852633-25-1 (2S,4R)-2-Methoxymethyl-4-(toluene-4-sulfonyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-24-0 (2R,4R)-2-Methoxymethyl-4-(toluene-4-sulfonyloxy)-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-23-9 4-(tert-butyl-dimethyl-silanyloxy)-2-methoxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-56-8 (2R,4S)-4-Dimethylcarbamoyl-2-methoxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-55-7 (2S,4S)-4-Dimethylcarbamoyl-2-methoxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852632-92-9 (3S,5R)-5-Methoxymethyl-5-(4-trifluoromethyl-benzyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 852632-91-8 (3S,5S)-5-Methoxymethyl-5-(4-trifluoromethyl-benzyl)-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 
• 852633-51-3 (2S,4S)-4-Cyano-2-methoxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-57-9 (2R,4S)-4-Cyano-2-methoxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 852633-22-8 4-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-2-(4-trifluoromethyl-benzyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis of 2,2-disubstituted pyrrolidine-4-carboxylic acid derivatives and their incorporation into β-peptide oligomers

(Chemical Equation Presented) We have recently shown that members of a new class of β-peptides, containing 2,2-disubstituted pyrrolidine-4-carboxylic acid residues, display discrete conformational preferences despite the impossibility of internal hydrogen bonding (Huck et al. J. Am. Chem. Soc. 2003, 125, 9035). Here we describe the synthesis of a variety of 2,2-disubstituted pyrrolidine-4-carboxylic derivatives that bear a diverse set of side chains and protecting groups suitable for oligomer synthesis. In addition, we discuss coupling methods for construction of oligomers in solution and on solid phase. Non-hydrogen bonded foldamers such as those generated from 2,2-disubstituted pyrrolidine-4-carboxylic acids may be useful in biomedical applications because the low intrinsic polarity of their backbones may promote bioavailability.