852674-75-0

Upstream product

• 142890-13-9 (S)-5-[(tert-butyl)-diphenylsilyloxy-methyl]-2-thiopyrrolidinone 
• 74-88-4 methyl iodide 
• 17342-08-4 (S)-Pyroglutaminol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 

Downstream Products

• 869287-22-9 5-(tert-butyl-diphenyl-silanyloxymethyl)-4,5-dihydro-3H-pyrrol-2-ylamine 
• 1207721-49-0 C₄₃H₄₉N₃O₄Si 
• 869287-23-0 {4-[2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-3-yl]-pyrimidin-2-yl}-propyl-amine 
• 471844-88-9 2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-3-(2-methylsulfanyl-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 
• 926659-97-4 (S)-5-((tert-butyldiphenylsilyloxy)methyl)-2-(4-fluorophenyl)-6,7-dihydro-5Hpyrrolo[1,2-a]imidazole 
• 869287-24-1 [2-(4-fluoro-phenyl)-3-(2-propylamino-pyrimidin-4-yl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol 
• 471844-84-5 2-(4-fluoro-phenyl)-5-(4-methoxy-benzyloxymethyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole 
• 471844-82-3 [2-(4-fluoro-phenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-5-yl]-methanol 

Relevant academic research and scientific papers

An N-acyliminium cyclization approach to a total synthesis of (+)-cylindricine C

Details of problems and solutions encountered during the development of an enantioselective total synthesis of (+)-cylindricine C are described here. The total synthesis itself was accomplished in 8 steps, featuring an N-acyliminium cyclization strategy,

The neuroprotective action of JNK3 inhibitors based on the 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole scaffold

Imidazole-based structures of p38 inhibitors served as a starting point for the design of JNK3 inhibitors. Construction of a 6,7-dihydro-5H-pyrrolo[1,2-a] imidazole scaffold led to the synthesis of the (S)-enantiomers, which exhibited p38/JNK3 IC50 ratio of up to 10 and were up to 20 times more potent inhibitors of JNK3 than the relevant (R)-enantiomers. The JNK3 inhibitory potency correlated well with inhibition of c-Jun phosphorylation and neuroprotective properties of the compounds in low K+-induced cell death of rat cerebellar granule neurones.