852705-10-3Relevant academic research and scientific papers
A PROCESS FOR THE PREPARATION OF HIGH PURITY ESCITALOPRAM
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Page/Page column 12, (2008/06/13)
The present invention discloses an improved process for the preparation of high purity escitalopram base of formula (I) by reacting the acid addition salt of formula (XVIII) with copper (I) cyanide and with or without copper (I) iodide in dimethylformamide medium at 145-150 °C. Cyanation on the acid addition salt of formula (XVIII) is found to be superior in yield and quality over the parent base compound of formula (XVII). The process is compatible to scale up operations thereby making the process commercially viable for escitalopram oxalate. Escitalopram oxalate is an antidepressant available in the market.
