85274-02-8Relevant academic research and scientific papers
Synthesis and 5-Hydroxytryptamine Antagonist Activity of 2-thio>-3-phenylquinoline and Its Analogues
Blackburn, Thomas P.,Cox, Barry,Guildford, Allen J.,Count, David J. Le,Middlemiss, Derek N.,et al.
, p. 2252 - 2259 (2007/10/02)
A series of 2-quinolines substituted at the 3-position with alkyl, aryl, or heteroaryl groups has been prepared in the search for novel and selective 5-HT2 antagonists.The affinity of the compounds for 5-HT1 recep
Quinoline derivatives which are 5-hydroxytryptamine antagonists
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, (2008/06/13)
Compounds of the formula: STR1 wherein A stands for the radical --(CH2)2 -- which may bear one or two defined substituents; R1 stands for a (3-4C) alkyl or cyclopropyl radical, or a phenyl radical which may optionally bear one or two defined substituents, or a heteroaryl radical of five or six ring atoms which may optionally bear a (1-3C)alkyl substituent; R2 and R3 stand for hydrogen or a (1-2C)alkyl radical, or R2 stands for a (2-4C)alkylene radical which is linked to one of the carbon atoms forming the two-carbon-atom-backbone of A so as to form, together with the adjacent nitrogen atom, a pyrrolidinyl or piperidyl radical; and one of R4 and R5 stands for hydrogen, and the other stands for hydrogen, a halogen atom or a (1-3C)alkyl or (1-3C)alkoxy radical; and acid-addition salts thereof. Processes for the manufacture of said compounds. Pharmaceutical compositions comprising one of said compounds and a pharmaceutical diluent or carrier. The compounds are 5-hydroxytryptamine antagonists.
