2859-30-5

Usage

Uses

Used in Organic Synthesis:
2-Chloro-3-phenylquinoline is used as a versatile building block in the synthesis of various organic compounds. Its unique structure allows for the formation of different derivatives, contributing to the development of novel chemical entities.
Used in Pharmaceutical Industry:
2-Chloro-3-phenylquinoline is used as a key intermediate in the preparation of pharmaceuticals. Its potential biological activities, such as antibacterial and antifungal properties, make it a valuable compound for the development of new drugs and medicinal compounds.
Used in Agrochemical Industry:
2-Chloro-3-phenylquinoline is used as a starting material in the synthesis of agrochemicals. Its ability to form various derivatives makes it suitable for the development of new pesticides and other agrochemical products.
Used in Research and Development:
2-Chloro-3-phenylquinoline is used as a research compound to explore its potential applications in drug discovery and development. Its unique structure and biological activities make it an attractive candidate for further investigation and optimization to develop new therapeutic agents.

InChI:InChI=1/C15H10ClN/c16-15-13(11-6-2-1-3-7-11)10-12-8-4-5-9-14(12)17-15/h1-10H

Upstream product

• 38035-81-3 3-phenyl-1H-quinolin-2-one 
• 621-06-7 2,N-diphenylacetamide 
• 68-12-2 N,N-dimethyl-formamide 
• 25308-72-9 3-phenylquinoline N-oxide 
• 101-97-3 Ethyl 2-phenylethanoate 
• 103-82-2 phenylacetic acid 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 1581720-74-2 N-methoxy-2-phenyl-2-propenamide 
• 247222-84-0 2-(2-phenylethynyl)phenyl isocyanide 
• 13141-39-4 N-<2-(2-Phenylethynyl)phenyl>methanamide 
• 113092-93-6 3-Chloro-3-phenyl-3,4-dihydro-1H-quinolin-2-one 
• 71910-54-8 (E)-3-(2-Aminophenyl)-2-phenyl-2-propenoic acid 
• 19319-35-8 (E)-2-phenyl-3-(2-nitrophenyl)propenoic acid 
• 1022-66-8 3-phenyl-1,2,3,4-tetrahydro-2-quinolone 

Downstream Products

• 113093-00-8 2-[4-(3-Phenyl-quinolin-2-yl)-piperazin-1-yl]-ethanol 
• 85273-96-7 ICI 169369 
• 1202574-33-1 N-(3-methoxyphenyl)-3-phenylquinolin-2-amine 
• 1202574-34-2 N-(4-ethylphenyl)-3-phenylquinolin-2-amine 
• 22514-82-5 2,3-diphenyl quinoline 
• 243-38-9 6H-quinindoline 
• 114414-78-7 neocryptolepine 
• 113092-97-0 3-Phenyl-2-piperazin-1-yl-quinoline 
• 85275-10-1 2-<<2-(N-ethyl-N-methylamino)ethyl>thio>-3-phenylquinoline 
• 85273-95-6 2-<<2-(N,N-dimethylamino)ethyl>thio>-3-phenylquinoline 
• 85274-03-9 2-<<2-(N-methylamino)ethyl>thio>-3-phenylquinoline 
• 85275-09-8 2-(2-(N-methyl-N-acetylamino)ethylthio)-3-phenylquinoline 
• 85274-02-8 3-phenyl-2(1H)-thioquinolone 
• 110487-07-5 2-(3-Phenyl-quinolin-2-ylsulfanyl)-ethylamine 

Relevant academic research and scientific papers

Azide-Triggered Bicyclization of o-Alkynylisocyanobenzenes: Synthesis of Tetrazolo[1,5-a]quinolines

An efficient and rapid synthetic approach for the synthesis of tetrazolo[1,5-a]quinolines has been developed employing the reaction of o-alkynylisocyanobenzenes with sodium azide. The present strategy involved nucleophilic addition of azide to isocyanide followed by 6-endo cyclization. The reaction gives access to a collection of tetrazolo[1,5-a]quinolines with broad functional group in moderate to high yields under metal-, and base-free conditions.

An elegant synthesis of indoloquinoline alkaloid cryptotackieine via Vilsmeier-Haack approach

An exclusive approach towards the synthesis of indoloquinoline alkaloid cryptotackiene has been illustrated. Primary starting materials with an established procedure like Vilsmeier-Haack cyclization are used followed by nucleophilic azidation, intra-molecular cyclization and a selective methylation to achieve the target.

Synthesis of quinolinones with palladium-catalyzed oxidative annulation between acrylamides and arynes

An unprecedented palladium-catalyzed oxidative annulation of acrylamides with benzyne precursors has been successfully developed. By using this mild "N-H activation/Heck reaction" method, a wide variety of quinolinones were conveniently prepared in one st

Synthesis of 2-halogenated quinolines by halide-mediated intramolecular cyclization of o-alkynylaryl isocyanides

When o-alkynylaryl isocyanides 1 are treated with triethylamine in chloroform, intramolecular chlorinating cyclization of the isocyanides takes place, affording the corresponding 2-chlorinated quinoline derivatives 2 in good to excellent yields, selective

Tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes: an efficient synthesis of 2-chloro-3-substituted quinolines

A highly efficient one-pot synthesis of 2-chloro-3-substituted quinolines has been developed by tetrabutylammonium chloride-triggered 6-endo cyclization of o-alkynylisocyanobenzenes, which are generated in situ by dehydration of the corresponding N-(2-eth

Synthesis of 4-Aryl-2-aminopyridine derivatives and related compounds

A short, efficient, and high-yielding synthesis of 4-aryl-2-aminopyridine derivatives has been developed. The route employs two palladium-catalyzed processes, the Suzuki reaction and the Buchwald-Hartwig amination, as the key steps. The same approach has

A Versatile New Synthesis of Quinolines and Related Fused Pyridines. Part 8. Conversion of Anilides into 3-Substituted Quinolines and into Quinoxalines

Anilides (4) (ArNHCOCH2R) are readily converted into 2-chloro-3-R-quinolines (5) under Vilsmeier conditions and the 3-chloro-group may be removed with zinc and acetic acid yielding 3-substituted quinolines (7).When N-nitrosodialkylamines are used in place of dimethylformamide as the Vilsmeier agent, the anilides are converted into 2-chloroquinoxalines in low yields.Several by-products are formed and the mechanisms have been explored.Thus, the formation of ethyl N-arylcarbamate from the corresponding propionanilide is shown to involve an C->O alkyl migration related to a Wolff rearrangement, while N-arylformimidoyl dichloride (18), nitriles, and isocyanides are derived from C-C cleavage of the substituted side-chain.Variation of the acid chloride component of the Vilsmeier reagent or of the solvent was generally unproductive though use of phosphoryl bromide instead of the chloride caused conversion of anilides into bromoquinolines in low yields.

Carbostyril derivatives used as coccidiostats

Carbostyril derivatives useful as coccidiostats are prepared by reacting an ortho-halo benzaldehyde with a 2-alkyl-2-oxazoline, then heating at above about 200° C thereby forming the carbostyril.