852810-63-0

Upstream product

• 100-44-7 benzyl chloride 
• 102019-30-7 4-O-benzyl-3,5-diacetoxybenzoic acid methyl ester 
• 20189-90-6 3,4,5-triacetoxy-benzoic acid methyl ester 
• 99-24-1 methyl galloate 
• 91925-82-5 3,5-dihydroxy-4-(phenylmethoxy)benzoic acid methyl ester 
• 74-88-4 methyl iodide 
• 3934-86-9 methyl 3,4-dihydroxy-5-methoxybenzoate 
• 100-39-0 benzyl bromide 

Downstream Products

• 852810-65-2 2-benzyloxy-5-hydroxymethyl-3-methoxy-phenol 
• 958883-52-8 4-benzyloxy-3-hydroxy-5-methoxybenzoic acid 
• 52179-44-9 graphislactone A 
• 852810-75-4 2-benzyloxy-6-iodo-4-methoxy-benzoic acid 2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-phenyl ester 
• 852810-77-6 4,7-bis-benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3,9-dimethoxy-benzo[c]chromen-6-one 
• 852810-93-6 2-iodo-4,6-dimethoxy-benzoic acid 2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-phenyl ester 
• 852810-94-7 4-benzyloxy-1-(tert-butyl-dimethyl-silanyloxymethyl)-3,7,9-trimethoxy-benzo[c]chromen-6-one 
• 852810-89-0 2-benzyloxy-6-iodo-4-methoxy-benzoic acid 2-benzyloxy-3-methoxy-5-methyl-phenyl ester 
• 852810-91-4 4,7-bis-benzyloxy-3,9-dimethoxy-1-methyl-benzo[c]chromen-6-one 
• 852810-96-9 4-benzyloxy-1-hydroxymethyl-3,7,9-trimethoxy-benzo[c]chromen-6-one 
• 852810-98-1 10-benzyloxy-11-hydroxy-2,4,9-trimethoxy-7H-dibenzo[c,e]oxepin-5-one 
• 852810-85-6 2-iodo-4,6-dimethoxy-benzoic acid 2-benzyloxy-3-methoxy-5-methyl-phenyl ester 
• 852810-87-8 4-benzyloxy-3,7,9-trimethoxy-1-methyl-benzo[c]chromen-6-one 
• 852810-67-4 2-benzyloxy-5-(tert-butyl-dimethyl-silanyloxymethyl)-3-methoxy-phenol 

Relevant academic research and scientific papers

Radiosynthesis of 3-(3-[18F]fluoropropoxy)-4-(benzyloxy)-N-[(1- dimethylaminocyclopentyl)methyl]-5-methoxybenzamide, a potential PET radiotracer for the glycine transporter GlyT-2

The recently described selective and potent GlyT2 antagonist, 4-benzyloxy-3, 5-dimethoxy-N-[(1-dimethylaminocyclopentyl) methyl]benzamide (IC50 = 16 nM) provided an important additional tool to further characterize GlyT2 pharmacology. In order to identify an effective PET radioligand for in vivo assessment of the GlyT-2 transporter, 3-(3-[ 18F]fluoropropoxy)-4-(benzyloxy)-N-((1-dimethylaminocyclopentyl) methyl)-5-methoxybenzamide ([18F]3), a novel analog of 4-benzyloxy-3,5-dimethoxy-N-[(1-dimethylaminocyclopentyl) methyl]benzamide was synthesized using a one-pot, two-step method. The NCA radiofluorination of 1,3-propanediol di-p-tosylate in the presence of K2CO3 and Kryptofix-222 in acetonitrile gave 81% 3-[18F]fluoropropyl tosylate, which was subsequently coupled with 4-benzyloxy-3-hydroxy-5-methoxy-N-[(1- dimethylaminocyclopentyl) methyl]-benzamide in the same reaction vessel. Solvent extraction and HPLC (Eclipse XDB-C8 column, 80/20/0.1 MeOH/H 2O/Et3N, 3.0 ml/min) gave [18F]3 in 98.5% radiochemical purity. The radiochemical yield was determined to be 14.0-16.2% at EOS, and the specific activity was 1462 ± 342 GBq/μmol. The time of synthesis and purification was 128 min. The final product was prepared as a sterile saline solution suitable for in vivo use. Copyright

Synthesis of graphislactones A-D through a palladium-mediated biaryl coupling reaction of phenyl benzoate derivatives

The chemical synthesis of graphislactones A-D was achieved through the Pd-mediated intramolecular biaryl coupling reaction of phenyl benzoate derivatives.