852819-02-4Relevant academic research and scientific papers
Discovery of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective human prostaglandin EP4 receptor antagonists
Hattori, Kouji,Tanaka, Akira,Fujii, Naoaki,Takasugi, Hisashi,Tenda, Yoshiyuki,Tomita, Masayuki,Nakazato, Shoko,Nakano, Keiko,Kato, Yasuko,Kono, Yutaka,Murai, Hidetsugu,Sakane, Kazuo
, p. 3103 - 3106 (2007/10/03)
Two novel classes of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective EP4 antagonists have been discovered. The optimized diphenyloxzole 8 and Nδ-Z-ornithine 11 effectively competed with [3H]-PGE2/s
ORNITHINE DERIVATIVES AS PROSTAGLANDIN E2 AGONISTS OR ANTAGONISTS
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Page/Page column 31-32, (2010/02/12)
Ornithine derivatives of the formula (I): wherein X is -CO- or -(CH2) k- (wherein k is 1, 2 or 3); Y is Z-(CH2) n-, and the like; {wherein Z is R1-CO-NR4-, and the like, (wherein R1 is aryl, and the like; and R4 is hydrogen, or lower alkyl); and n is 1, 2, 3, 4, 5 or 6}; R2 is aryl-(lower alkyl), and the like; R3 is -Q-R7, [wherein Q is -CO- or -SO2-, R7 is heterocyclyl], and the like; and R5 and R6 are independently hydrogen or lower alkyl; or a pharmaceutically acceptable salt thereof, which are useful as medicament.
