852831-45-9

Basic information

• Product Name: 12α-hydroxybufalin
• Synonyms: 12α-hydroxybufalin
• CAS NO: 852831-45-9
• Molecular Weight: 402.531
• Mol File: 852831-45-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 12α-hydroxybufalin(CAS DataBase Reference)
• NIST Chemistry Reference: 12α-hydroxybufalin(852831-45-9)
• EPA Substance Registry System: 12α-hydroxybufalin(852831-45-9)

Safety Data

• Hazardous Substances Data: 852831-45-9(Hazardous Substances Data)

Upstream product

• 465-20-3 bufalin 

Relevant articles and documents

Microbial hydroxylation of bufalin by Cunninghamella blakesleana and Mucor spinosus

The microbial transformation of a cytotoxic bufadienolide, bufalin (1), was carried out using two strains of filamentous fungi. Cunninghamella blakesleana catalyzed the specific 12α-hydroxylation of bufalin and produced 12α-hydroxybufalin (2) and 7β,12α-dihydroxybufalin (3) as the major metabolites, together with 7β-hydroxybufalin (4) and 12β-hydroxybufalin (5) in low yields. Two minor products were isolated from the culture broth of Mucor spinosus and were identified as 7β,15α- dihydroxybufalin (6) and 5β,7β-dihydroxybufalin (7), respectively. Metabolites 2, 3, 6, and 7 are new compounds, and their structures were fully characterized by NMR and MS spectroscopy.