852853-00-0

Upstream product

• 852853-20-4 N-nosyl-L-isoleucine chloride 
• 95102-01-5 H-D-Ala-Val-OMe 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 73-32-5 L-isoleucine 
• 852852-81-4 3-methyl-2-(4-nitrophenylsulphonamido)pentanoic acid 
• 198836-35-0 (S)-2-(4-nitrobenzenesulfonylamino)-3-methyl-butyric acid methyl ester 
• 6306-52-1 L-valine methylester hydrochloride 
• 4070-48-8 L-Valine methyl ester 
• 852852-96-1 methyl 3-methyl-2-(S)-(2-(R)-(4-nitrophenylsulfonamido)propanamido)butanoate 

Downstream Products

• 852853-09-9 N-(N-(N-methyl-N-nosyl-L-isoleucyl)-D-alanyl)-L-valine methyl ester 

Relevant academic research and scientific papers

N-Nosyl-α-amino acids in solution phase peptide synthesis

A highly efficient and practical synthesis of peptides in solution phase has been developed. The procedure is based on the use of p-nitrobenzenesulfonyl (nosyl) group for the protection of the amino function of α-amino acids. Every step of the procedure,

N-methylation of peptides on selected positions during the elongation of the peptide chain in solution phase

An efficient and general solution-phase method for the site-specific N-methylation of peptides has been developed. This novel procedure involves synthesis of N-nosyl protected peptides and their subsequent N-methylation with diazomethane. Its efficiency w