85288-45-5

Upstream product

• 20628-06-2 2-hydroxy-4,5-dimethoxyacetophenone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 1818-28-6 2',4',5'-trimethoxyacetophenone 
• 1818-27-5 1-(2,4,5-trihydroxyphenyl)ethanone 
• 57601-14-6 2'-hydroxy-3,4,4'-trimethoxychalcone 
• 109469-82-1 2',5'-dihydroxy-3,4,4'-trimethoxy-trans-chalcone 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 76622-27-0 3′,4′,6,7‐tetramethoxyflavone 
• 24126-93-0 6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-4H-chromen-4-one 
• 97080-90-5 2-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-chroman-4-one 

Relevant academic research and scientific papers

Hydroxyaurone derivative as well as preparation method and application thereof

The invention relates to a hydroxyaurone derivative as well as a preparation method and application thereof. A monomeric compound aurone separated from Kunlun chrysanthemum in Xinjiang is used as a mother nucleus compound, hydroxyl is introduced into auro

Flavonoids with M1 muscarinic acetylcholine receptor binding activity

Muscarinic acetylcholine receptor- Active compounds have potential for the treatment of Alzheimer's disease. In this study, a series of natural and synthetic flavones and flavonols was assayed in vitro for their ability to inhibit radioligand binding at human cloned M1 muscarinic receptors. Several compounds were found to possess competitive binding affinity (K i = 40-110 μM), comparable to that of acetylcholine (Ki = 59 μM). Despite the fact that these compounds lack a positively-charged ammonium group under physiological conditions, molecular modelling studies suggested that they bind to the orthosteric site of the receptor, mainly through non-polar interactions.

13C Nuclear Magnetic Resonance Studies on 1,3-Diphenylprop-2-enones

The 13C NMR spectra of 48 differently substituted chalcones (1,3-diphenylprop-2-enones) have been recorded and the results are discussed.The data will be useful in the identification of new/natural chalcones.