85289-90-3

Basic information

• Product Name: 1-(1-chloroethyl)-4-(trifluoromethyl)benzene
• Synonyms: 1-(1-chloroethyl)-4-(trifluoromethyl)benzene
• CAS NO: 85289-90-3
• Molecular Formula: C₉H₈ClF₃
• Molecular Weight: 208.6080296
• Mol File: 85289-90-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(1-chloroethyl)-4-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-chloroethyl)-4-(trifluoromethyl)benzene(85289-90-3)
• EPA Substance Registry System: 1-(1-chloroethyl)-4-(trifluoromethyl)benzene(85289-90-3)

Safety Data

• Hazardous Substances Data: 85289-90-3(Hazardous Substances Data)

Upstream product

• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 27190-69-8 1-ethyl-4-(trifluoromethyl)benzene 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 402-51-7 4-(trifluoromethyl)phenylmagnesium bromide 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 

Downstream Products

• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 134904-86-2 2-Methyl-2-(4-trifluoromethylphenyl)acetic acid 

Relevant articles and documents

Cu-Catalyzed Site-Selective Benzylic Chlorination Enabling Net C–H Coupling with Oxidatively Sensitive Nucleophiles

Site-selective chlorination of benzylic C–H bonds is achieved using a CuICl/bis(oxazoline) catalyst with N-fluorobenzenesulfonimide as the oxidant and KCl as a chloride source. This method exhibits higher benzylic selectivity, relative to estab

Ferric chloride–catalyzed deoxygenative chlorination of carbonyl compounds: A comparison of chlorodimethylsilane and dichloromethylsilane system

Deoxygenative chlorination of carbonyl compounds using the HMe2SiCl/FeCl3/EtOAc and HMeSiCl2/FeCl3/EtOAc systems has been systemically investigated. The HMe2SiCl-FeCl3 system showed the advantages of good substrate applicability, mild reaction conditions, simple operation, low cost, and easy availability of raw materials. Also, it provided a simple and efficient synthesis route for carbonyl deoxychlorination via a one-pot method. Using the HMeSiCl2/FeCl3/EtOAc system, the β-methylchalcone derivative could be obtained in good yields in addition to obtaining the chlorinated compound. Finally, two plausible reaction routes were proposed to describe the formation of the chlorinated compound and the β-methylchalcone derivative.

Iron catalyzed halogenation of benzylic aldehydes and ketones

A simple and efficient iron-catalyzed method for chlorination of aromatic carbonyl compounds is reported. By using 4-10 mol% Fe(iii) oxo acetate catalyst, prepared by solid state atmospheric oxidation of Fe(ii) acetate, in combination with triethylsilane and chlorotrimethylsilane, hydrosilylation of benzylic carbonyl compounds with subsequent chlorination is achieved within a few hours at room temperature. This new method is mild and rapid compared to the conventional two step approach involving reduction and chlorination reactions in separate stages. Development of synthetic methodology is also supplemented here by kinetic investigation of the reaction mechanism, which supports the tentative mechanisms suggested previously for similar reactions. This journal is