852947-56-9Relevant academic research and scientific papers
Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis
Runfola, Massimiliano,Sestito, Simona,Bellusci, Lorenza,La Pietra, Valeria,D'Amore, Vincenzo Maria,Kowalik, Marta Anna,Chiellini, Grazia,Gul, Sheraz,Perra, Andrea,Columbano, Amedeo,Marinelli, Luciana,Novellino, Ettore,Rapposelli, Simona
, (2020)
Although triiodothyronine (T3) induces several beneficial effects on lipid metabolism, its use is hampered by toxic side-effects, such as tachycardia, arrhythmia, heart failure, bone and muscle catabolism and mood disturbances. Since the α isoform of thyroid hormone receptors (TRs) is the main cause of T3-related harmful effects, several efforts have been made to develop selective agonists of the β isoform that could induce some beneficial effects (i.e. lowering triglyceride and cholesterol levels reducing obesity and improving metabolic syndrome), while overcoming most of the adverse T3-dependent side effects. Herein, we describe the drug discovery process sustained by ADME-Toxicity analysis that led us to identify novel agonists with selectivity for the isoform TRβ and an acceptable off-target and absorption, distribution metabolism, excretion and toxicity (ADME-Tox) profile. Within the small series of compounds synthesized, derivatives 1 and 3, emerge from this analysis as “potentially safe” to be engaged in preclinical studies. In in vitro investigation proved that both compounds were able to reduce lipid accumulation in HepG2 and promote lipolysis with comparable effects to those elicited by T3, used as reference drug. Moreover, a preliminary in vivo study confirmed the apparent lack of toxicity, thus suggesting compounds 1 and 3 as new potential TRβ-selective thyromimetics.
NOVEL THYROMIMETICS WITH A BIPHENYLMETHANE SCAFFOLD AND THEIR USE
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, (2020/12/01)
The invention concerns a compound of Formula (I) or a salt thereof, wherein R1 is H, (C1-C3)alkyl or CF3; R2 is H, (C1-C3)alkyl or CF3; A is CH2COOH, XCH2COOCH2CH3, XCH2COOH, XCH2CH2NH2, where X is nitrogen or oxygen atom; Ar is an aromatic fragment selected from the group consisting of (Ar1), (Ar2) and (Ar3); where R3 is H, -CH3, -CH2CH3 or CH3CO-, R4 is H or -CH3, R5 is H or -CH3, and R6 is H or -CH3. The compounds of Formula (I) can be used in the treatment of diseases modulated by thyroid hormone receptor-beta (TRb or TRβ).
