852990-39-7

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione
• Synonyms: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione
• CAS NO: 852990-39-7
• Molecular Weight: 330.337
• Mol File: 852990-39-7.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione(852990-39-7)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione(852990-39-7)

Safety Data

• Hazardous Substances Data: 852990-39-7(Hazardous Substances Data)

Upstream product

• 931407-28-2 [(Tetrahydro-pyran-2-yloxy)-(3,4,5-trimethoxy-phenyl)-methyl]-phosphonic acid dimethyl ester 
• 130190-35-1 dimethyl α-hydroxy-α-(3,4,5-trimethoxyphenyl)methanephosphonate 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 141172-33-0 3,4,5-trimethoxy-α-[(4-methoxyphenyl)methylene]-(E)-benzeneacetic acid 
• 208347-68-6 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)acetylene 
• 134029-49-5 3,4,5,4'-tetramethoxy-cis-stilbene 

Downstream Products

• 874-90-8 4-methoxybenzonitrile 
• 852990-40-0 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime 

Relevant articles and documents

Design, synthesis and biological evaluation of 3,4-diaryl-1,2,5-oxadiazole-2/5-oxides as highly potent inhibitors of tubulin polymerization

Structure-activity relationships for rigid analogues of combretastatin A-4 (CA-4) were investigated, leading to the discovery of a series of 3,4-diaryl-1,2,5-oxadiazole-N-oxides. Among them, 7n′ and 7n′′ showed remarkable antiproliferative activities agai

Synthesis and biological evaluation of novel 3,4-diaryl-1,2,5-selenadiazol analogues of combretastatin A-4

A set of novel selenium-containing heterocyclic analogues of combretastatin A-4 (CA-4) have been designed and synthesised using a rigid 1,2,5-selenadiazole as a linker to fix the cis-orientation of ring-A and ring-B. All of the target compounds were evalu

Synthesis and antitumor activity of benzils related to combretastatin A-4

A series of benzil derivatives related to combretastatin A-4 (CA-4) have been synthesized by oxidation of diarylalkynes promoted by PdI2 in DMSO. Using this new protocol, 14 benzils were prepared in good to excellent yields and their biological

Microwave-assisted efficient synthesis of 1,2-diaryldiketones: a novel oxidation reaction of diarylalkynes with DMSO promoted by FeBr3

This paper reports the oxidation of functionalized diarylalkynes with DMSO in the presence of the environmentally friendly FeBr3 catalyst. This non-toxic procedure is general and has been applied successfully under microwave irradiation leading rapidly to benzil derivatives in good yields.

Synthesis and cytotoxic evaluation of combretafurazans

Combretastatin A-4 is an antitumoral and antitubulin agent that is active only in its cis configuration. In the present manuscript, we have synthesized cis-locked combretastatins embodying a furazan ring (combretafurazans). To achieve this, we have developed a new strategy that exploits the dehydration of vicinal dioximes using the Mitsunobu reaction. Among the advantages of following such a strategy are the mild conditions used for the construction of the diarylfurazan derivatives, allowing for the presence of highly functionalized substrates and deactivated aromatic rings. Combretafurazans are more potent in vitro cytotoxic compounds compared to combretastatins in neuroblastoma cells, yet maintaining similar structure-activity relationship and pharmacodynamic profiles.