852990-40-0

Basic information

• Product Name: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime
• Synonyms: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime
• CAS NO: 852990-40-0
• Molecular Weight: 360.367
• Mol File: 852990-40-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime(852990-40-0)
• EPA Substance Registry System: 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione dioxime(852990-40-0)

Safety Data

• Hazardous Substances Data: 852990-40-0(Hazardous Substances Data)

Upstream product

• 134029-49-5 3,4,5,4'-tetramethoxy-cis-stilbene 
• 141172-33-0 3,4,5-trimethoxy-α-[(4-methoxyphenyl)methylene]-(E)-benzeneacetic acid 
• 852990-39-7 1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-1,2-ethanedione 

Downstream Products

• 874-90-8 4-methoxybenzonitrile 

Relevant articles and documents

Synthesis and cytotoxic evaluation of combretafurazans

Combretastatin A-4 is an antitumoral and antitubulin agent that is active only in its cis configuration. In the present manuscript, we have synthesized cis-locked combretastatins embodying a furazan ring (combretafurazans). To achieve this, we have developed a new strategy that exploits the dehydration of vicinal dioximes using the Mitsunobu reaction. Among the advantages of following such a strategy are the mild conditions used for the construction of the diarylfurazan derivatives, allowing for the presence of highly functionalized substrates and deactivated aromatic rings. Combretafurazans are more potent in vitro cytotoxic compounds compared to combretastatins in neuroblastoma cells, yet maintaining similar structure-activity relationship and pharmacodynamic profiles.