853-82-7Relevant academic research and scientific papers
A facile access for the C-N bond formation by transition metal-free oxidative coupling of benzylic C-H bonds and amides
Liu, Jie,Zhang, Heng,Yi, Hong,Liu, Chao,Lei, Aiwen
, p. 1323 - 1328 (2015/08/11)
Using 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ) as the oxidant, we communicate an efficient oxidative C-N coupling of benzylic C-H bonds with amides to afford a series of amination products in good yields. A wide range of functional groups as well as various sulfonamides and carboxamides are well tolerated. Moreover, this reaction involves both the challenging C-H functionalization and C-N bond formation.
DDQ-mediated direct oxidative coupling of amides with benzylic and allylic sp3 C-H bonds under metal-free conditions
Ramesh,Ramulu,Mukkanti,Venkateswarlu
experimental part, p. 2904 - 2908 (2012/07/27)
A simple and efficient method for the direct oxidative coupling of amides with benzylic and allylic sp3 C-H bonds using DDQ as an oxidant is described. A range of amides including benzamide, benzyl carbamate, and substituted sulfonamides reacted efficiently with various benzylic and allylic substrates under metal free conditions to afford amidation products in good to excellent yields.
Cobalt-catalyzed benzylic C-H amination via dehydrogenative-coupling reaction
Ye, Yang-Hong,Zhang, Ji,Wang, Gao,Chen, Shan-Yong,Yu, Xiao-Qi
supporting information; experimental part, p. 4649 - 4654 (2011/06/27)
An efficient direct benzylic C-H amination via dehydrogenative-coupling by using an inexpensive catalyst/oxidant (CoBr2/tBuOO tBu) system is described. Various unmodified amides including primary or secondary sulfonamides, carboxamides, and carbamates preformed well with benzylic hydrocarbons with moderate to good yields.
