853001-89-5

Upstream product

• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 786689-37-0 2-chloro-4-[(5-fluoroquinazolin-4-yl)amino]phenol 

Downstream Products

• 853001-90-8 N-[2-({4-[3-chloro-4-hydroxyanilino]quinazolin-5-yl}oxy)ethyl]-2-hydroxy-N-methylacetamide 

Relevant academic research and scientific papers

Neutral 5-substituted 4-anilinoquinazolines as potent, orally active inhibitors of erbB2 receptor tyrosine kinase

Neutral 5-substituted 4-anilinoquinazolines addressed high in vivo clearance and phospholipidosis associated with previous basic compounds. A representative compound 8a inhibited tumor growth in a mouse xenograft model when co-administered with the cytoch

QUINAZOLINE DERIVATIVES

A quinazoline derivative of the Formula (I): wherein the substituents are as defined in the text for use in the production of an anti proliferative effect which effect is produced alone or in part by inhibiting erbB2 receptor tyrosine kinase in a warm-blooded animal such as man.