85301-74-2Relevant academic research and scientific papers
Indeno[1,2-c]pyrazolone acetic acids as semirigid analogues of the nonsteroidal anti-inflammatory drugs
Lemke,Abebe,Moore,Carty
, p. 343 - 347 (2007/10/02)
A series of 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-2-acetic acids (3a-e) and 3-substituted indeno[1,2-c]pyrazol-4(1H)-one-1-acetic acids (4a-e) were synthesized as semirigid analogues of tolmetin (1). These compounds were evaluated for their anti-inflammatory action by investigating their ability to block arachidonic acid metabolism in vitro as well as the ability to block carrageenan-induced rat foot edema in vivo. No consistent pattern of biological activity was noted.
The Regiospecific Synthesis of N-Substituted Pyrazoles. I. 1- and 2-Substituted Indenopyrazol-4(1H)-ones
Lemke, Thomas L.,Sawhney, Kailash N.
, p. 1335 - 1340 (2007/10/02)
The reaction of enaminoketones (2 or 5) of 2-acyl-1,3-indandiones with unsymmetrical hydrazines results in the regiospecific synthesis of 1,3- or 2,3-disubstituted indenopyrazol-4(1H)-ones (4 or 7).The synthesis of the enaminoketones (2 or 5) is accomplished by way of amine addition to the 2-acyl-1,3-indandiones 8a-c or by reduction of the indenoisoxazole 9.The structural assignment of the isomeric indenopyrazoles 4 and 7 is based upon 1H-nmr chemical shifts.
