853020-70-9

Upstream product

• 853020-71-0 1-(2-phenoxyethyl)pyrrolidin-3-ol 

Downstream Products

• 853019-30-4 6-bromo-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] 
• 853018-34-5 7-fluoro-1'-(2-phenoxyethyl)-2,3,4,9-tetrahydrospiro[β-carboline-1,3'-pyrrolidine] 

Relevant academic research and scientific papers

NOVEL BETA-CARBOLINES AS GROWTH HORMONE SECRETAGOGUE RECEPTOR (GHSR) ANTAGONISTS

The present invention relates to compounds of Formula (I): Formula (I) wherein R-R, X, and Y are as described herein, processes for preparing the compounds, pharmaceutical compositions comprising the compounds, and use of the compounds and compositions in the prophylaxis or treatment of a GHSR receptor-related disorder. Examples of such disorders are obesity and related disorders such as diabetes type II, dyslipidemia and the metabolic syndrome Prader-Willi syndrome, cardiovascular diseases such as atherosclerotic vascular disease, angina pectoris, myocardial infarction and stroke, acromegaly and cancer, in particular breast, lung, prostate, thyroid and endocrine pituary carcinomas.