853023-12-8

Upstream product

• 415900-37-7 (Z)-(10S)-11-(tert-butyldimethylsilyloxy)-3-hydroxy-6,10-dimethyl-5-undecen-2-one 
• 3966-32-3 (R)-methoxyphenylacetic acid 
• 412042-96-7 (Z)-2-acetoxy-2-acetyl-5,9-dimethyldeca-4,8-dienoic acid tert-butyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 415899-96-6 (Z)-(10S)-3-acetoxy-11-hydroxy-6,10-dimethyl-5-undecen-2-one 
• 415899-95-5 (Z)-(9S)-2-acetoxy-2-acetyl-5,9-dimethyl-10-hydroxydeca-4-enoic acid tert-butyl ester 
• 796965-84-9 (4Z,8E)-2-acetoxy-2-acetyl-5,9-dimethyl-10-hydroxy-deca-4,8-dienoic-acid-tert-butylester 

Downstream Products

• 853023-13-9 (R)-α-methoxyphenylacetic acid Z-(1S,8S)-9-(tert-butyldimethylsilyloxy)-4,8-dimethyl-1-[(1E)-1-methyl-2-(2-methylthiazol-4-yl)-vinyl]-non-3-enyl ester 
• 853023-15-1 (R)-α-methoxyphenylacetic acid Z-(1S,8S)-9-(tert-butyldimethylsilyloxy)-4,8-dimethyl-1-[(1E)-1-methyl-2-(2-methyloxazol-4-yl)-vinyl]-non-3-enyl ester 
• 189453-10-9 epothilone D 

Relevant academic research and scientific papers

Total synthesis of epothilone D: The nerol/macroaldolization approach

A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.

THIAEPOTHILONE FOR TREATING CANCEROUS DISEASES

The invention relates to novel macrocycles of general formula (I) and to the use thereof for treating cancerous diseases.