Journal of Organic Chemistry p. 10588 - 10595 (2013)
Update date:2022-08-03
Topics:
Wessjohann, Ludger A.
Scheid, Guenther O.
Eichelberger, Uwe
Umbreen, Sumaira
A highly convergent and stereocontrolled synthesis of epothilone D (4) is reported. Key features are a cheap and Z-selective synthesis of the northern half based on nerol and acetoacetate and chromium(II)-mediated Reformatsky reactions as a powerful tool for chemoselective asymmetric carbon-carbon bond formations, including an unusual stereospecific macroaldolization.
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