853052-23-0

Upstream product

• 1022-86-2 2-benzoylindole 
• 106-96-7 propargyl bromide 

Downstream Products

• 853052-27-4 {1-[3-(4-chloro-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-phenyl-methanone 
• 914983-15-6 1-phenyl-3H-pyrrolo[1,2-a]indole-2-carbaldehyde 
• 853052-28-5 phenyl-{1-[3-(3-trifluoromethyl-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-methanone 
• 853052-29-6 {1-[3-(4-methoxy-phenyl)-prop-2-ynyl]-1H-indol-2-yl}-phenyl-methanone 
• 853052-26-3 phenyl[1-(3-phenylprop-2-ynyl)-1H-indol-2-yl]methanone 

Relevant academic research and scientific papers

TiCl4/t-BuNH2-promoted hydroamination/annulation of δ-keto-acetylenes: Synthesis of novel pyrrolo[1,2-a]indol-2-carbaldehydes

(Chemical Equation Presented) An original TiCl4/t-BuNH 2-mediated hydroamination/annulation domino reaction of δ-keto-acetylenes is described. The synthesis of pyrrolo[1,2-a]indole-2- carbaldehydes, starting from 2-carbonyl-1-proparg

Synthesis and antibacterial activity of substituted 1,2,3,4- tetrahydropyrazino [1,2-a] indoles

A series of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indole derivatives have been synthesized and tested against the Gram positive and Gram negative strains of bacteria namely Staphylococcus aureus (MTCCB 737), Salmonella typhi (MTCCB 733), Pseudomonas aeruginosa (MTCCB 741), Streptomyces thermonitrificans (MTCCB 1824) and Escherichia coli (MTCCB 1652). All synthesized compounds showed mild to moderate activity. However, compounds 4d-f were found to have potent activity against pathogenic bacteria used in the study. Their MIC ranged from 3.75 to 60 μg/disc. In vitro toxicity tests demonstrated that toxicity of 4d-f was not significantly different than that of gentamycin. However, at higher concentration (1000-4000 μg/ml) difference was highly significant.

Intramolecular cyclization of δ-iminoacetylenes: A new entry to pyrazino[1,2-a]indoles

The synthesis of the pyrazino[1,2-a]indole nucleus was achieved by intramolecular cyclization of several 2-carbonyl-1-propargylindoles in the presence of ammonia. The reaction conditions were optimized using microwave heating and a pool of catalysts. Cycl