853055-08-0

Upstream product

• 3446-89-7 4-(Methylthio)benzaldehyde 
• 189500-95-6 2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[4-(trifluoromethyl)phenyl]-1H-pyrrole 
• 189501-34-6 1-[4-(methylsulfonyl)phenyl]pentane-1,4-dione 
• 189501-33-5 1-[4-(methylthio)phenyl]pentane-1,4-dione 
• 455-14-1 4-trifluoromethylphenylamine 
• 853055-05-7 [5-(4-methanesulfonyl-phenyl)-2-methyl-1-(4-trifluoromethyl-phenyl)-1H-pyrrol-3-yl]-oxo-acetic acid ethyl ester 

Downstream Products

• 1005451-96-6 3-(2-hydroxyethyl)-2-methyl-5-[(4-methylsulfonyl)phenyl]-1-(4-trifluoromethyl)phenyl-1H-pyrrole 

Relevant academic research and scientific papers

1,5-Diarylpyrrole-3-acetic acids and esters as novel classes of potent and highly selective cyclooxygenase-2 inhibitors

A small set of substituted 1,5-diarylpyrrole-3-acetic and -glyoxylic acid derivatives have been synthesized, and their cyclooxygenase (COX-1 and COX-2) inhibiting properties have been evaluated. Some compounds proved to be highly selective COX-2 inhibitors, and their affinity data have been rationalized through docking simulations in terms of interactions with a crystallographic model of the COX-2 binding site.