853056-24-3Relevant academic research and scientific papers
Synthesis and antinematodal activity of 3-n-alkylphenols
Takaishi, Kazuto,Alen, Yohannes,Kawazu, Kazuyoshi,Baba, Naomichi,Nakajima, Shuhei
, p. 2398 - 2400 (2004)
Several 3-alkylphenols including 3-undecylphenol, which was isolated from a Sumatran rainforest plant, were synthesized to investigate their antinematodal activity against the phytopathogenic nematodes, Bursapherencus xylophilus. A three-step synthesis involving the treatment of 2-cyclohexen-1-one with the Grignard reagent, oxidation of the resulting 1-alkyl-2-cyclohexen-1-ol and subsequent aromatization of 3-alkyl-2-cyclohexen-1-one successfully afforded such phenols. Among the 3-alkylphenols, 3-nonylphenol showed the highest activity, while 3-decylphenol and 3-undecylphenol also showed high activity.
