103151-49-1

Basic information

• Product Name: 3-Heptylphenol
• Synonyms: 3-Heptylphenol
• CAS NO: 103151-49-1
• Molecular Formula: C₁₃H₂₀O
• Molecular Weight: 0
• Mol File: 103151-49-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Heptylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Heptylphenol(103151-49-1)
• EPA Substance Registry System: 3-Heptylphenol(103151-49-1)

Safety Data

• Hazardous Substances Data: 103151-49-1(Hazardous Substances Data)

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 629-04-9 1-Bromoheptane 
• 106522-92-3 1-heptyl-3-methoxybenzene 
• 586-38-9 3-Methoxybenzoic acid 
• 100863-37-4 1-(3-methoxyphenyl)heptan-1-one 
• 68266-37-5 1-(3-methoxyphenyl)hexanol 
• 13125-66-1 n-heptylmagnesium bromide 
• 853056-24-3 1-heptyl-2-cyclohexen-1-ol 
• 145364-82-5 3-heptyl-2-cyclohexen-1-one 
• 106380-12-5 1-(3-hydroxy-phenyl)-heptan-1-ol 
• 132858-49-2 1-(3-hydroxyphenyl)-1-heptanone 
• 3761-92-0 n-hexylmagnesium bromide 

Downstream Products

• 108240-88-6 isovaleric acid-(3-heptyl-phenyl ester) 
• 110051-83-7 2-heptyl-4-hydroxy-5-isopentyl-isophthalaldehyde 
• 102020-40-6 6-heptyl-2-hydroxy-3-isopentyl-benzaldehyde 
• 102175-05-3 5-Heptyl-2-isopentyl-phenol 
• 101873-66-9 1-(4-heptyl-2-hydroxy-phenyl)-3-methyl-butan-1-one 

Relevant articles and documents

A 'meta effect' in the fragmentation reactions of ionised alkyl phenols and alkyl anisoles

The competition between benzylic cleavage (simple bond fission [SBF]) and retro-ene rearrangement (RER) from ionised ortho, meta and para RC 6H4OH and RC6H4OCH3 (R = n-C3H7, n-C4H9, n-C5H11, n-C7H15, n-C9H19, n-C 15H31) is examined. It is observed that the SBF/RER ratio is significantly influenced by the position of the substituent on the aromatic ring. As a rule, phenols and anisoles substituted by an alkyl group in meta position lead to more abundant methylene-2,4-cyclohexadiene cations (RER fragmentation) than their ortho and para homologues. This 'meta effect' is explained on the basis of energetic and kinetic of the two reaction channels. Quantum chemistry computations have been used to provide estimate of the thermochemistry associated with these two fragmentation routes. G3B3 calculation shows that a hydroxy or a methoxy group in the meta position destabilises the SBF and stabilises the RER product ions. Modelling of the SBF/RER intensities ratio has been performed assuming two single reaction rates for both fragmentation processes and computing them within the statistical RRKM formalism in the case of ortho, meta and para butyl phenols. It is clearly demonstrated that, combining thermochemistry and kinetics, the inequality (SBF/RER) metaorthopara holds for the butyl phenols series. It is expected that the 'meta effect' described in this study enables unequivocal identification of meta isomers from ortho and para isomers not only of alkyl phenols and alkyl anisoles but also in other alkyl benzene series. Copyright

Scope and limitations of lithium-ethylenediamine-THF-mediated cleavage at the α-position of aromatics: Deprotection of aryl methyl ethers and benzyl ethers under mild conditions

The scope and limitation of lithium-ethylenediamine-THF-mediated reductive bond cleavage at the α-position of aromatics were examined. Very mild conditions such as lithium metal (5 equiv) and ethylenediamine (7 equiv) in oxygen-free THF were quite effective for the demethylation of aromatic ethers even at as low as -10°C. Allyl benzyl ethers were also deprotected under these conditions with very little change of the allylic alcohol moiety. Through this study, 2,6-dimethylbenzyl (m-xylylmethyl, MXM) group was developed as an alternative of benzyl group, which is readily cleavable under the above mentioned reductive conditions.