853070-29-8

Upstream product

• 138786-86-4 methyl 4-nitro-1H-pyrazole-3-carboxylate 
• 853070-33-4 methyl 1-(4-methoxybenzyl)-4-nitro-1H-pyrazole-5-carboxylate 

Relevant academic research and scientific papers

Tankyrase inhibitor

The invention belongs to the technical field of medicines and particularly relates to a tankyrase inhibitor represented by a general formula (I) shown in the description and pharmaceutically acceptable salts, esters, solvates or stereoisomers thereof, wherein R1, R2, R3, m, n, Z, L, Q, A, X1, X2 and Y are as defined in the description. The invention further relates to a preparation method for the compounds, pharmaceutical preparations and pharmaceutical compositions containing the compounds and application of the compound and the pharmaceutically acceptable salts, esters, solvates or stereoisomers thereof in preparation of drugs for treating and/or preventing tankyrase mediated cancers and related diseases.

Tankyrase inhibitor

The invention belongs to the technical field of medicines and particularly relates to a tankyrase inhibitor shown in the general formula (I) and pharmaceutically acceptable salt, ester, solvates or stereisomers thereof, wherein R1, R2, R3, R4, R5, m, n, p, Z, L, X and Y are defined in the description. The invention also relates to a preparation of the compounds, a drug preparation and a drug composition containing the compounds and application of the compounds, the pharmaceutically acceptable salt, ester, solvates or stereisomers thereof in preparation of a drug for treating and/or preventing cancer mediated by tankyrase and relevant diseases.

ACYLATED PIPERIDIHES AS GLYCINE TRANSPORTER INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.

PIPERAZINE DERIVATIVES AS GLYT1 INHIBITORS

The invention provides a compound of formula (I) or a salt or solvate thereof: wherein R1, n, X, Y and Z are as defined in the specification, and uses of such compounds. The compounds inhibit GlyT1 transporters and are useful in the treatment of certain neurological and neuropsychiatric disorders, including schizophrenia.