853070-33-4Relevant academic research and scientific papers
Tankyrase inhibitor
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Paragraph 0283-0295, (2017/10/13)
The invention belongs to the technical field of medicines and particularly relates to a tankyrase inhibitor represented by a general formula (I) shown in the description and pharmaceutically acceptable salts, esters, solvates or stereoisomers thereof, wherein R1, R2, R3, m, n, Z, L, Q, A, X1, X2 and Y are as defined in the description. The invention further relates to a preparation method for the compounds, pharmaceutical preparations and pharmaceutical compositions containing the compounds and application of the compound and the pharmaceutically acceptable salts, esters, solvates or stereoisomers thereof in preparation of drugs for treating and/or preventing tankyrase mediated cancers and related diseases.
Tankyrase inhibitor
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Paragraph 0158-0160, (2017/10/31)
The invention belongs to the technical field of medicines and particularly relates to a tankyrase inhibitor shown in the general formula (I) and pharmaceutically acceptable salt, ester, solvates or stereisomers thereof, wherein R1, R2, R3, R4, R5, m, n, p, Z, L, X and Y are defined in the description. The invention also relates to a preparation of the compounds, a drug preparation and a drug composition containing the compounds and application of the compounds, the pharmaceutically acceptable salt, ester, solvates or stereisomers thereof in preparation of a drug for treating and/or preventing cancer mediated by tankyrase and relevant diseases.
NOVEL CONDENSED IMIDAZOLE DERIVATIVE
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Page/Page column 180, (2010/11/23)
Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R2 and R3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R4 and R5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R6 represents a hydrogen atom, an optionally substituted aryl group or the like; and -Y-NH2, represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R7 may not exist or one or two R7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.]
