85319-64-8Relevant articles and documents
Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids
Gaunt, Matthew J.,Boschetti, Carlos E.,Yu, Jinquan,Spencer, Jonathan B.
, p. 1803 - 1806 (1999)
Selective hydrogenolysis of 2-naphthylmethyl (NAP) esters in the presence of a benzyl ester has been observed with a wide range of dicarboxylic acids. Orthogonal deprotection of NAP esters with challenging substrates can be achieved if the other carboxylic acids in the molecule are protected with 4-trifluoromethyl benzyl group instead of benzyl groups.