85322-12-9

Upstream product

• 51238-73-4 5-methoxy-4,6,7,8-tetrahydro-3H-naphthalen-2-one 
• 2844-80-6 1,2,3,4,5,8-hexahydro-1-oxo-6-methoxynaphthalene 
• 175774-65-9 (R)-3,4,8,8a-tetrahydro-8a-allyl-1,6-(2H,7H)-naphthalenedione 
• 154471-43-9 3,4,8,8a-tetrahydro-8a(2-bromo-cyclopentenylmethyl)-1,6(2H,7H)-naphthalenedione 
• 140-88-5 ethyl acrylate 
• 154471-45-1 8a-Benzyl-3,4,8,8a-tetrahydro-2H,7H-naphthalene-1,6-dione 
• 85322-11-8 6-benzylamino-3,4,7,8-tetrahydronaphthalen-1(2H)-one 

Relevant academic research and scientific papers

An Unusual Radical Fragmentation of 8a-Cycloalkenylmethyl Wieland-Miescher Ketones Mediated by Tri-n-butyltin Hydride

The behaviour of tri-n-butyltin hydride in poly functional molecule like Wieland-Miescher ketones, was found to be very unusual, a remarkable difference in chemoselectivity was noticed in the reductive cyclisation of cycloalkenyl bromides, resulting in the remote generation of the bromocyclopentenyl-methyl radical by a homolytic C-C bond cleavage.

Fused polycyclic heterocycle derivatives

Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: STR1 wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula --e--f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity.

Enantioselective synthesis of a Wieland-Miescher ketone bearing an angular hydroxymethyl group

The enantioselective synthesis of (R)-3,4,8,8a-tetrahydro-8a-allyl-1,6-(2H,7H)-naphthalenedione and the degradation of the angular allyl group to a hydroxymethyl group are reported.

An Authentic Synthesis of Bicyclodec-Δ1(6)-ene-2,6-dione

The synthesis of the title compound has been achieved.Some ambiguity regarding its structure and that of the product obtained from Birch reduction of 6-methoxy-1-tetralone has been clarified.