853245-47-3

Upstream product

• 88050-17-3 N-Fmoc-trans-4-Hydroxy-L-Proline 
• 99-34-3 3,5-dinitrobenzoic acid 
• 468096-64-2 4-hydroxypyrrolidine-1,2-dicarboxylic acid 2-allyl ester 1-(9H-fluoren-9-ylmethyl) ester 

Relevant academic research and scientific papers

A practical solid-phase synthesis of Glu7-phalloidin and entry into fluorescent F-actin-binding reagents

Simple synthesis of a potent probe: An efficient solid-phase synthesis of Glu7-phalloidin (the resin-bound cyclic peptide shown) features the one-pot I2-mediated deprotection of S-tritylcysteine and formation of the Cys-Trp thioether bridge. A fluorescent conjugate of the resulting phalloidin analogue shows specific staining of F-actin (filamentous actin) in fixed mammalian epithelial cells (see fluorescence micrograph). Fmoc = 9-fluorenylmethoxycarbonyl. (Chemical Equation Presented).

A solid-phase approach to the phallotoxins: Total synthesis of [Ala 7]-phalloidin

Herein we report a solid-phase synthetic approach to [Ala 7]-phalloidin (1). Prior syntheses of phallotoxins were carried out using solution-phase routes that required large scale and preclude library production. The route presented here consis