85330-63-8

Basic information

• Product Name: 2,5-BIS(METHYLSULFONYL)PYRIDINE
• Synonyms: 2,5-BIS(METHYLSULFONYL)PYRIDINE
• CAS NO: 85330-63-8
• Molecular Formula: C₇H₉NO₄S₂
• Molecular Weight: 235.28
• Mol File: 85330-63-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 508.492°C at 760 mmHg
• Flash Point: 261.327°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.531
• CAS DataBase Reference: 2,5-BIS(METHYLSULFONYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-BIS(METHYLSULFONYL)PYRIDINE(85330-63-8)
• EPA Substance Registry System: 2,5-BIS(METHYLSULFONYL)PYRIDINE(85330-63-8)

Safety Data

• Hazardous Substances Data: 85330-63-8(Hazardous Substances Data)

Usage

General Description

2,5-BIS(METHYLSULFONYL)PYRIDINE is a chemical compound with the molecular formula C9H10N2O4S2. It is a white to off-white crystalline solid that is used as a reagent in organic synthesis. The compound is often employed as a building block in the production of pharmaceuticals and agrochemicals. 2,5-BIS(METHYLSULFONYL)PYRIDINE is also known for its ability to act as a mild, selective and efficient methanesulfonylation agent for a wide range of organic compounds. Additionally, it is used as a key intermediate in the synthesis of various biologically active compounds.

InChI:InChI=1/C7H9NO4S2/c1-13(9,10)6-3-4-7(8-5-6)14(2,11)12/h3-5H,1-2H3

Upstream product

• 85330-62-7 2,5-bis(methylsulfanyl)pyridine 
• 624-28-2 2,5-dibromopyridine 
• 5188-07-8 sodium thiomethoxide 
• 1532-24-7 methyl 3,6-dichloro-2-pyridinecarboxylate 
• 85330-61-6 3,6-bis-methylthiopyridine-2-carboxylic acid 
• 85330-65-0 2,5-bis-methylethylthiopyridine 
• 51933-78-9 5-bromo-2-(methylsulfanyl)pyridine 
• 1702-17-6 Clopyralid 

Downstream Products

• 99902-97-3 2-(3,4-dichlorophenoxy)-5-(methylsulfonyl)pyridine 
• 142-08-5 2-Pyridone 
• 103058-99-7 3-[2-chloro-5-(methylsulfonyl)-3-pyridinyl]-1-(3,4-dichlorophenyl)propan-1-ol 
• 103058-94-2 3-<2-Methoxy-5-(methylsulfonyl)-3-pyridinyl>-1-(3,4-dichlorophenyl)-propan-1-one 
• 103058-98-6 3-<2-Chloro-5-(methylsulfonyl)-3-pyridinyl>-1-(3,4-dichlorophenyl)propan-1-one 
• 102830-69-3 2-(3,4-Dichlorophenyl)-3,4-dihydro-6-(methylsulfonyl)-2H-pyrano<2,3-b>pyridine 
• 721430-01-9 2-ethoxy-5-methylsulfonylpyridine 
• 605681-82-1 C₁₂H₁₇NO₅S 
• 18085-51-3 5-methanesulfonyl-1H-pyridin-2-one 

Relevant articles and documents

HETEROARYLCARBAMOYLBENZENE DERIVATIVE

Compounds having glucokinase activating effects and being useful as treatments for diabetes, which are represented by the following formula (I): [wherein X1 represents oxygen, etc., X2 represents oxygen, etc., R1 represents a group on Ring A such as alkylsulfonyl, etc., R2 represents C3-7 cyclic alkyl optionally substituted with a halogen, etc., R3 represents a substituent on Ring B such as lower alkyl, etc., formula (II): represents 6- to 10-membered aryl, etc., and formula (III): represents monocyclic or bicyclic heteroaryl optionally having on Ring B a substituent represented by R3 above, wherein the carbon atom of Ring B which is bonded to the nitrogen atom of the amide group of formula (I) forms a C=N bond with the nitrogen atom of the ring], as well as their pharmaceutically acceptable salts.

2,5-bis alkyl sulfonyl and 2,5-bis alkyl thio substituted-pyridines

A process for preparing substituted-pyridines having a sulfonyl type substituted at the 3 or 5 position of the pyridine ring and a phenoxy type substituent at the 2 position is described.

bis-Alkylsulfonylpyridines

Dihalogenated pyridines, some activated with carboxylic, ester or cyano group, were allowed to react with sodium alkylmercaptides.After hydrolysis of the ester or cyano group followed by decarboxylation, bis-alkylthiopyridines with substituents at 2,3-, 2,4-, 2,5-, 2,6- and 3,5-positions were prepared.These compounds were oxidized to bis-alkylsulfonylpyridines.