85333-09-1Relevant academic research and scientific papers
Antiulcer Agents. 3. Structure-Activity-Toxicity Relationships of Substituted Imidazopyridines and a Related Imidazopyrazine
Kaminski, James J.,Perkins, D. G.,Frantz, J. D.,Solomon, Daniel M.,Elliott, Arthur J.,et al.
, p. 2047 - 2051 (2007/10/02)
Investigation of the interrelationship between structure, antiulcer activity, and toxicology screening data derived from a series of compounds selected from structure-activity studies directed toward identifying a successor to 3-(cyanomethyl)-2-methyl-8-(phenylmethoxy)imidazopyridine, Sch 28080 (1), has identified 3-(cyanomethyl)-2,7-dimethyl-8-(phenylmethoxy)imidazopyridine (5), 3-amino-2-methyl-8-(2-phenylethyl)imidazopyridine (6), and 3-amino-2-methyl-8-(phenylmethoxy)imidazopyrazine (7).These analogues exhibit a combination of antisecretory and cytoprotective activity in animal models, while eliminating the adverse effects of the prototype 1.One of these, 3-amino-2-methyl-8-(phenylmethoxy)imidazopyrazine, Sch 32651 (7), has a profile meeting all criteria.
