85335-79-1

Upstream product

• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 127880-87-9 4-amino-7-(2-deoxy-2-azido-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-85-7 4-amino-5-cyano-7-(2-deoxy-2-azido-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-96-0 4-amino-5-cyano-7-(2-deoxy-2-iodo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-86-8 4-amino-5-cyano-7-(2-deoxy-2-amino-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127913-81-9 4-amino-5-cyano-7-(2-deoxy-2-bromo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-88-0 4-amino-7-(2-deoxy-2-amino-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-97-1 4-amino-7-(2-deoxy-2-iodo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-94-8 4-amino-7-(2-deoxy-2-bromo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 85335-80-4 Thiocarbonic acid O-[(2R,3R,3aR,9aR)-2-(4-amino-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester O-phenyl ester 

Relevant academic research and scientific papers

NUCLEIC ACID RELATED COMPOUNDS. 42. A GENERAL PROCEDURE FOR THE EFFICIENT DEOXYGENATION OF SECONDARY ALCOHOLS. REGIOSPECIFIC AND STEREOSELECTIVE CONVERSION OF RIBONUCLEOSIDES TO 2 prime -DEOXYNUCLEOSIDES.

Treatment of unhindered secondary alcohols with phenoxythiocarbonyl chloride (phenyl chlorothionocarbonate) in pyridine/dichloromethane, or in acetonitrile with 4-dimethylaminopyridine catalysis for hindered alcohols, gave clean conversion to their O-phenoxythiocarbonyl derivatives. Reductive deoxygenation of these phenyl thionocarbonate esters proceeded smoothly, using tri-n-butyltin hydride and a free radical initiator in warm toluene. Overall conversion yields ranged from 57 to 78% for the naturally occurring nucleosides, nucleoside antibiotics, and methyl beta -D-ribofuranoside.