85335-79-1

Basic information

• Product Name: 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine
• Synonyms: 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine
• CAS NO: 85335-79-1
• Molecular Weight: 533.775
• Mol File: 85335-79-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine(85335-79-1)
• EPA Substance Registry System: 4-amino-5-cyano-7-<3,5-O-<1,1,3,3-tetrakis(methylethyl)disiloxan-1,3-diyl>-β-D-ribofuranosyl>pyrrolo<2,3-d>pyrimidine(85335-79-1)

Safety Data

• Hazardous Substances Data: 85335-79-1(Hazardous Substances Data)

Upstream product

• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 

Downstream Products

• 127880-87-9 4-amino-7-(2-deoxy-2-azido-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-85-7 4-amino-5-cyano-7-(2-deoxy-2-azido-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-96-0 4-amino-5-cyano-7-(2-deoxy-2-iodo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-86-8 4-amino-5-cyano-7-(2-deoxy-2-amino-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127913-81-9 4-amino-5-cyano-7-(2-deoxy-2-bromo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine 
• 127880-88-0 4-amino-7-(2-deoxy-2-amino-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-97-1 4-amino-7-(2-deoxy-2-iodo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 127880-94-8 4-amino-7-(2-deoxy-2-bromo-β-D-arabinofuranosyl)pyrrolo<2,3-d>pyrimidine-5-carboxamide 
• 85335-80-4 Thiocarbonic acid O-[(2R,3R,3aR,9aR)-2-(4-amino-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester O-phenyl ester 

Relevant articles and documents

NUCLEIC ACID RELATED COMPOUNDS. 42. A GENERAL PROCEDURE FOR THE EFFICIENT DEOXYGENATION OF SECONDARY ALCOHOLS. REGIOSPECIFIC AND STEREOSELECTIVE CONVERSION OF RIBONUCLEOSIDES TO 2 prime -DEOXYNUCLEOSIDES.

Treatment of unhindered secondary alcohols with phenoxythiocarbonyl chloride (phenyl chlorothionocarbonate) in pyridine/dichloromethane, or in acetonitrile with 4-dimethylaminopyridine catalysis for hindered alcohols, gave clean conversion to their O-phenoxythiocarbonyl derivatives. Reductive deoxygenation of these phenyl thionocarbonate esters proceeded smoothly, using tri-n-butyltin hydride and a free radical initiator in warm toluene. Overall conversion yields ranged from 57 to 78% for the naturally occurring nucleosides, nucleoside antibiotics, and methyl beta -D-ribofuranoside.