853406-81-2Relevant academic research and scientific papers
A cyclooligomerisation approach to backbone-modified cyclic peptides bearing guanidinium arms
Black, Richard J.G.,Dungan, Victoria J.,Li, Rebecca Y.T.,Young, Philip G.,Jolliffe, Katrina A.
supporting information; experimental part, p. 551 - 554 (2010/09/18)
Cyclooligomerisation of the pentafluorophenyl ester derivatives of oxazoles, derived from dipeptides containing protected ornithine, diaminobutanoic acid and diaminopropionic acid residues, gives the cyclic trimers as the major products. Deprotection and treatment with guanidinylating agents provides efficient access to backbone rigidified cyclic peptides with guanidinium functionalised side chains. Georg Thieme Verlag Stuttgart.
Structural mimicry of two cytochrome b562 interhelical loops using macrocycles constrained by oxazoles and thiazoles
Singh, Yogendra,Stoermer, Martin J.,Lucke, Andrew J.,Guthrie, Tom,Fairlie, David P.
, p. 6563 - 6572 (2007/10/03)
A major chemical challenge is the structural mimicry of discontinuous protein surfaces brought into close proximity through polypeptide folding. We report the design, synthesis, and solution structure of a highly functionalized saddle-shaped macrocyclic s
