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853574-45-5

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853574-45-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 853574-45-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,3,5,7 and 4 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 853574-45:
(8*8)+(7*5)+(6*3)+(5*5)+(4*7)+(3*4)+(2*4)+(1*5)=195
195 % 10 = 5
So 853574-45-5 is a valid CAS Registry Number.

853574-45-5Relevant academic research and scientific papers

Triazoloamides as potent γ-secretase modulators with reduced hERG liability

Fischer, Christian,Zultanski, Susan L.,Zhou, Hua,Methot, Joey L.,Shah, Sanjiv,Nuthall, Hugh,Hughes, Bethany L.,Smotrov, Nadja,Hill, Armetta,Szewczak, Alexander A.,Moxham, Christopher M.,Bays, Nathan,Middleton, Richard E.,Munoz, Benito,Shearman, Mark S.

scheme or table, p. 3140 - 3146 (2012/06/04)

Synthesis and SAR studies of novel aryl triazoles as gamma secretase modulators (GSMs) are presented in this communication. Starting from our aryl triazole leads, optimization studies were continued and the series progressed towards novel amides and lactams. Triazole 57 was identified as the most potent analog in this series, displaying single-digit nanomolar Aβ42 IC 50 in cell-based assays and reduced affinity for the hERG channel.

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