853642-87-2

Upstream product

• 853642-86-1 8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride 
• 2905-21-7 2-fluorobenzenesulfonyl chloride 
• 88-75-5 2-hydroxynitrobenzene 
• 28165-50-6 2-amino-6-bromophenol 
• 13073-25-1 2-bromo-6-nitro-phenol 
• 688363-73-7 8-bromo-2,2-dimethyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 853683-76-8 8-bromo-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazine 

Downstream Products

• 853642-88-3 4-[4-(2-fluoro-benzenesulfonyl)-2,2-dimethyl-3,4-dihydro-2H-benzo[1,4]oxazin-8-yl]-piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

3,4-Dihydro-2H-benzo[1,4]oxazine derivatives as 5-HT6 receptor antagonists

A series of novel 3,4-dihydro-2H-benzo[1,4]oxazine derivatives has been designed and synthesized as 5-HT6 receptor antagonists. Many of the compounds displayed subnanomolar affinities for the 5-HT6 receptor and good brain penetration in rats. The relationship of structure and lipophilicity to hERG inhibition of this series of compounds is discussed.

Benzoxazine derivatives and uses thereof

Compounds of the formula (I): or pharmaceutically acceptable salts, solvates or prodrugs thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9, X, Y and m are as defined herein. Also provided are compositions comprising, methods for using, and methods for preparing compound of formula (I).

Benzoxazine derivatives and uses thereof

The present invention provides a compound of the formula: a pharmaceutically acceptable salt or a prodrug thereof, where R1, R2, R3, R4, R5, R6, R7, R8, R9,