853658-51-2Relevant academic research and scientific papers
Water soluble prodrugs of COX-2 inhibitors
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Page/Page column 14; 15, (2008/06/13)
Disclosed are water soluble compounds which are useful as prodrugs of COX-2 inhibitors, and pharmaceutical compositions comprising them.
Novel approach to pro-drugs of lactones: Water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor
Poon, Steve F.,Stock, Nicholas,Payne, Joseph E.,McGuire, Angela R.,Stearns, Brian,Yang, Xiaoqing,Chen, Weichao,Munoz, Benito,Smith, Nicholas D.
, p. 2259 - 2263 (2007/10/03)
Interest in water soluble COX-2 inhibitors that can be administered intravenously led to the development of novel pro-drugs of a furanone based COX-2 inhibitor 2. Transforming the lactone moiety of the furanone to an imidate or an ortho-ester with a hydro
